ArticleJapanese journal of cancer research : Gann1993
A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat.
Article in Japanese journal of cancer research : Gann, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 38 citations in OpenAlex.
- Renal carcinogenesis: genotype, phenotype and dramatype.Cancer science · 2003Review
- A novel renal carcinoma predisposing gene of the Nihon rat maps on chromosome 10.Japanese journal of cancer research : Gann · 2001Article
- A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.Japanese journal of cancer research : Gann · 2000Article
- A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.Japanese journal of cancer research : Gann · 2000Article
- Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.Japanese journal of cancer research : Gann · 1995Article
- cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.Nucleic acids research · 1995Article
- Isolation of microdissection clones from rat chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Renal carcinogenesis in the Eker rat.Journal of cancer research and clinical oncology · 1995Article
- Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Isolation of genes differentially expressed between the Yoshida sarcoma and long-survival Yoshida sarcoma variants: origin of Yoshida sarcoma revisited.Japanese journal of cancer research : Gann · 1994Article
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6 authors at 1 institution in 1 country.
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Abstract
Hereditary renal cell carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that this predisposing inherited gene is a tumor suppressor gene fitting Knudson's "two-hit" model. This study was designed to map the RC susceptibility gene in the Eker rat using backcross animals. Our present data clearly show that the RC gene is genetically linked to the protamine-1 gene (Lod score = 11.65) and the interleukin-3 gene (Lod score = 4.13), both of which are located on the proximal part of rat chromosome 10. Rat chromosome 10 is currently believed to have no syntenic relationship to human chromosome 3p, the presumed site of the putative tumor suppressor gene for human RC and the locus of von Hippel Lindau disease (affected patients develop multiple RCs). Thus, the Eker rat might have a mutation of a novel tumor suppressor gene related to renal carcinogenesis.
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