ReviewGene1993
The origin of genetic information: viruses as models.
Review in Gene, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients.Journal of virology · 2013Trial
- Fidelity Characterization of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and NADC30-like Strain.Viruses · 2024Article
- Primitive Oligomeric RNAs at the Origins of Life on Earth.International journal of molecular sciences · 2023Article
- Review
- Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2.Frontiers in molecular biosciences · 2021Article
- The LUCA and its complex virome.Nature reviews. Microbiology · 2020Review
- Impact of Nucleic Acid Sequencing on Viroid Biology.International journal of molecular sciences · 2020Review
- Article
- Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.Journal of virology · 2016Article
- Human genome regulation.Bioengineered · 2016Article
- The origin and evolution of ribonucleotide reduction.Life (Basel, Switzerland) · 2015Review
- Pragmatic turn in biology: From biological molecules to genetic content operators.World journal of biological chemistry · 2014Review
- Emotion: The Self-regulatory Sense.Global advances in health and medicine · 2014Article
- Article
- Evaluation of novel design strategies for developing zinc finger nucleases tools for treating human diseases.Biotechnology research international · 2014Article
- Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses.PLoS pathogens · 2014Article
- Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.The Journal of general virology · 2013Article
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Viral shape-shifting: norovirus evasion of the human immune system.Nature reviews. Microbiology · 2010Review
- Protein-mediated selective enclosure of early replicators inside of membranous vesicles: first step towards cell membranes.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A living entity can be described as a complex adaptive system which differs from any, however complex, chemical structure by its capability of functional self-organization based on the processing of information. If one asks, where does this information come from and what is its primary semantics, the answer is: information generates itself in feedback loops via replication and selection, the objective being 'to be or not to be'. This paper describes the theoretical framework of information-generating systems and provides experimental clues for some basic forms of genetic organization, such as molecular quasi-species, hypercyclic and compartmentalized RNA-protein assemblies. The results are primarily obtained with RNA viruses and virus-like systems. The experiments are carried out with the help of automated, computer-controlled bioreactors, called 'evolution machines', that may form the basis of a new 'evolutionary biotechnology'.
Indexed as
Identifiers
8276276What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.