ArticleBiophysical journal1993
Gating kinetics of the quisqualate-sensitive glutamate receptor of locust muscle studied using agonist concentration jumps and computer simulations.
Article in Biophysical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 34 citations in OpenAlex.
- Unraveling subunit cooperativity in homotetrameric HCN2 channels.Biophysical journal · 2012Article
- Desensitization and resensitization kinetics of glutamate receptor channels from Drosophila larval muscle.Biophysical journal · 1997Article
- Activation kinetics of glutamate receptor channels from wild-type Drosophila muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.Journal of computational neuroscience · 1994Review
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4 authors at 1 institution in 1 country.
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Abstract
Outside-out patches excised from extrajunctional membrane of locust muscle were subjected to "concentration jumps" of L-glutamate, using the liquid filament switch technique, to study channel opening and closing rates, desensitization onset, and recovery from desensitization of a quisqualate-sensitive glutamate receptor (qGluR). Based on data obtained from these experimental studies, computer modeling techniques have been used in an attempt to simulate the behavior of qGluR during a concentration jump of L-glutamate. A linear model with three closed states (one unliganded, one monoliganded, and one biliganded), one open state (binding two molecules of L-glutamate), and two desensitization states (the one monoliganded, the other biliganded) leading from the unliganded closed state simulated all of the experimentally observed behavior. The results are discussed in the context of previous equilibrium studies in which desensitization was inhibited with concanavalin A and for which a ten-state model was required to simulate the behavior of qGluR.
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