ArticlePharmaceutical research1993
Inhibition of the Friend retrovirus by antisense oligonucleotides encapsulated in liposomes: mechanism of action.
Article in Pharmaceutical research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 63 citations in OpenAlex.
- Versatility of Liposomes for Antisense Oligonucleotide Delivery: A Special Focus on Various Therapeutic Areas.Pharmaceutics · 2023Review
- Radiolabeled oligonucleotides for antisense imaging.Current organic synthesis · 2011Article
- Nanocarriers' entry into the cell: relevance to drug delivery.Cellular and molecular life sciences : CMLS · 2009Review
- Nanotechnology: intelligent design to treat complex disease.Pharmaceutical research · 2006Review
- Lysine: Is it worth more?Cytotechnology · 2001Article
- Preparation of functional liposomes with peptide ligands and their binding to cell membranes.Lipids · 2000Article
- Article
- Liposomes dispersed within a thermosensitive gel: a new dosage form for ocular delivery of oligonucleotides.Pharmaceutical research · 1998Article
- Application of antisense DNA method for the study of molecular bases of brain function and behavior.Behavior genetics · 1996Review
- Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto poly(isobutylcyanoacrylate) nanoparticles after intravenous administration in mice.Pharmaceutical research · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proliferation of the Friend retrovirus was specifically inhibited by the env mRNA complementary oligonucleotide encapsulated in pH-sensitive liposomes. This observation was made using the focus immunoassay (FIA) and the reverse transcriptase test. The key finding of the present study was the dramatic impact on liposome penetration. For chronic or de novo infection, the point at which the penetration of liposomes began corresponded to the time needed for the virus to leave the cell. In the absence of the virus, liposomes remained adsorbed onto the cell surface without any internalization. Regardless of the mechanism involved, the fact that a retroviral infection stimulates the cellular uptake of oligonucleotide liposomes widens the spectrum of strategies for specific antiviral action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.