ArticleThe Journal of membrane biology1993
Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux.
Article in The Journal of membrane biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase.Antimicrobial agents and chemotherapy · 2016Article
- Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells.Antimicrobial agents and chemotherapy · 2014Article
- Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.Neurochemical research · 2004Review
- Enhancement of iron toxicity in L929 cells by D-glucose: accelerated(re-)reduction.The Biochemical journal · 2002Article
- Signaling events during swelling and regulatory volume decrease.Neurochemical research · 2000Review
- Voltage-dependent K+ channels as targets of osmosensing in guard cellsThe Plant cell · 1998Article
- Swelling of rat mesangial cells induces a Ca2+-dependent Cl- conductance.Pflugers Archiv : European journal of physiology · 1996Article
- Hypotonically activated chloride current in HSG cells.The Journal of membrane biology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trypsinized human skin fibroblasts in suspension perform regulatory volume decrease (RVD) after cell swelling in hypotonic medium. During RVD, 36Cl- efflux is dramatically increased and the cell membrane is depolarized, indicating the activation of Cl- channels. This activation of Cl- channels depends on extracellular as well as on intracellular Ca2+. The swelling-induced Cl- efflux and the RVD response are inhibited by the 5-lipoxygenase inhibitor ETH 615-139. Finally, following hypotonic treatment, cellular pH decreases. The pH decrease does not involve the Cl-/HCO3- exchange because it is independent of the external Cl- concentration.
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Registered trials
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