ArticleDiabetologia1993
Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. The Belgian Diabetes Registry.
Article in Diabetologia, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 98 citations in OpenAlex.
- Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes.Pediatric diabetes · 2022Article
- Type 1 diabetes-related autoimmune antibodies in women with gestational diabetes mellitus and the long-term risk for glucose intolerance.Frontiers in endocrinology · 2022Article
- Influence of type 1 diabetes genes on disease progression: similarities and differences between countries.Current diabetes reports · 2012Review
- Latent Autoimmune Diabetes in Adults: Autoimmune Diabetes in Adults with Slowly Progressive β-cell Failure.Diabetes & metabolism journal · 2012Article
- Latent autoimmune diabetes in adults: A distinct but heterogeneous clinical entity.World journal of diabetes · 2010Article
- Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.Clinical and experimental immunology · 2007Article
- Type 1 diabetes: pathogenesis and prevention.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2006Review
- Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.Diabetologia · 2005Article
- Autoimmune diabetes: more than just one flavor?Journal of endocrinological investigation · 2004Review
- The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescence.Diabetologia · 2003Article
- Latent autoimmune diabetes in adults (LADA).Reviews in endocrine & metabolic disorders · 2003Review
- Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes.Clinical and experimental immunology · 2001Article
- Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.Clinical and experimental immunology · 1999Article
- Genetic analysis of type 1 diabetes using whole genome approaches.Proceedings of the National Academy of Sciences of the United States of America · 1995Review
- Age-dependent HLA genetic heterogeneity of IDDM in Japanese patients.Diabetologia · 1995Article
- Anti-37kDa antibodies are associated with the development of IDDM in individuals with islet cell antibodies.Diabetologia · 1995Article
- Relationships among 64k autoantibodies, pancreatic beta-cell function, HLA-DR antigens and HLA-DQ genes in patients with insulin-dependent diabetes mellitus in Korea.The Korean journal of internal medicine · 1995Article
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6 authors at 1 institution in 1 country.
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Abstract
Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20 years (1.0); no age-or sex-differences were noticed in serum fructosamine concentration. Total and high concentrations of insulin autoantibodies and islet cell antibodies were preferentially associated with the HLA DQA1*0301-DQB1*0302 susceptibility haplotype. The occurrence of both types of antibodies was also correlated, irrespective of haplotype. At onset before age 10 years, the high risk genotype DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 was more prevalent than all other DQA1-DQB1 genotypes taken together, leading to a higher prevalence of the DQA1*0301-DQB1*0302 haplotype in this age group (75%) than in the 10-39 years age group (54%). Under age 10 years, the presence of DQA1*0301-DQB1*0302 was strongly associated with insulin autoantibodies (90%) and islet cell autoantibodies (92% with 85% of high titre), whereas patients without this haplotype were less frequently positive for insulin autoantibodies (31%) or islet cell autoantibodies (38% high titre). In the group with onset at age 10-39 years, the DQA1*0301-DQB1*0302 haplotype presented a lower association with insulin autoantibodies (approximately 40%) and islet cell autoantibodies (50 to 65% high titre), prevalences which no longer differed from those in subjects lacking this haplotype.(ABSTRACT TRUNCATED AT 250 WORDS)
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