ReviewClinical microbiology reviews1993
Nonculture methods for diagnosis of disseminated candidiasis.
Review in Clinical microbiology reviews, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 138 citations in OpenAlex.
- Use of cost effective and rapid molecular tools for identification ofCurrent medical mycology · 2016Article
- Invasive Candida Infections in the ICU: Diagnosis and Therapy.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2015Review
- Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes.BMC oral health · 2015Article
- ECIL-3 classical diagnostic procedures for the diagnosis of invasive fungal diseases in patients with leukaemia.Bone marrow transplantation · 2012Review
- Simultaneous detection and identification of Aspergillus and mucorales species in tissues collected from patients with fungal rhinosinusitis.Journal of clinical microbiology · 2011Article
- Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study.BMC infectious diseases · 2010Article
- The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia.Critical care (London, England) · 2010Review
- Antifungal drug resistance: do molecular methods provide a way forward?Current opinion in infectious diseases · 2009Review
- Review
- Fungal infection in patients with serpiginous choroiditis or acute zonal occult outer retinopathy.Journal of clinical microbiology · 2008Article
- Catalase activity of different Candida species after exposition to specific antiserum.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2008Article
- Bench-to-bedside review: Candida infections in the intensive care unit.Critical care (London, England) · 2008Review
- Multicenter evaluation of the new VITEK 2 advanced colorimetric yeast identification card.Journal of clinical microbiology · 2007Article
- Simultaneous detection and identification of Candida, Aspergillus, and Cryptococcus species by reverse line blot hybridization.Journal of clinical microbiology · 2006Article
- [Infections under immunosuppressive therapy following organ transplantation].Der Internist · 2004Review
- Competitive binding inhibition enzyme-linked immunosorbent assay that uses the secreted aspartyl proteinase of Candida albicans as an antigenic marker for diagnosis of disseminated candidiasis.Clinical and diagnostic laboratory immunology · 2003Article
- Cross-reactivity of the PLATELIA CANDIDA antigen detection enzyme immunoassay with fungal antigen extracts.Journal of clinical microbiology · 2003Article
- Current status of nonculture methods for diagnosis of invasive fungal infections.Clinical microbiology reviews · 2002Review
- Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification.Journal of clinical microbiology · 2002Article
- Simple and rapid detection of Candida albicans DNA in serum by PCR for diagnosis of invasive candidiasis.Journal of clinical microbiology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two of the nonculture approaches to the diagnosis of DC, enzymatic-fluorometric determination of serum D-arabinitol and detection of marker antigens in antigenemia (enolase and CWMP), have been commercialized and have shown promise in limited clinical trials. These approaches are not new but are the culmination of efforts made over 10 or more years. Clearly, further fine-tuning of both metabolite and antigen detection is needed to simplify the methods and to improve their sensitivity and specificity so that they will be valuable in guiding clinical treatment decisions. An alternative approach, detection of DC by DNA amplification methods such as PCR, is a special case of a compelling technology and one that is capable of standardization across microbial genera. The availability of simplified PCR diagnostic methods for DC remains a tantalizing prospect. Nevertheless, the development of methods to release DNA from very small numbers of Candida organisms in the blood in a form that is sufficiently free of inhibitors of PCR will require further intensive effort. The maturation of these converging laboratory approaches to nonculture diagnosis of DC leads to more optimism about the eventual use of these methods in clinical laboratories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.