ArticleProceedings of the National Academy of Sciences of the United States of America1993
A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Host-like RNA Elements Regulate Virus Translation.Viruses · 2024Review
- Review
- Article
- Review
- Translational control of coronaviruses.Nucleic acids research · 2020Review
- Article
- Reselection of a genomic upstream open reading frame in mouse hepatitis coronavirus 5'-untranslated-region mutants.Journal of virology · 2014Article
- A leaderless genome identified during persistent bovine coronavirus infection is associated with attenuation of gene expression.PloS one · 2013Article
- An upstream open reading frame modulates ebola virus polymerase translation and virus replication.PLoS pathogens · 2013Article
- An optimal cis-replication stem-loop IV in the 5' untranslated region of the mouse coronavirus genome extends 16 nucleotides into open reading frame 1.Journal of virology · 2011Article
- Subgenomic messenger RNA amplification in coronaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Persistent equine arteritis virus infection in HeLa cells.Journal of virology · 2008Article
- The intraleader AUG nucleotide sequence context is important for equine arteritis virus replication.Virus genes · 2006Article
- Establishment of Vero E6 cell clones persistently infected with severe acute respiratory syndrome coronavirus.Microbes and infection · 2005Article
- Expression of cellular oncogene Bcl-xL prevents coronavirus-induced cell death and converts acute infection to persistent infection in progenitor rat oligodendrocytes.Journal of virology · 2005Article
- Stem-loop III in the 5' untranslated region is a cis-acting element in bovine coronavirus defective interfering RNA replication.Journal of virology · 2003Article
- Review
- Transcription regulatory sequences and mRNA expression levels in the coronavirus transmissible gastroenteritis virus.Journal of virology · 2002Article
- Comparison of the 5' leader sequences of North American isolates of reference and field strains of porcine reproductive and respiratory syndrome virus (PRRSV).Virus genes · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Short open reading frames within the 5' leader of some eukaryotic mRNAs are known to regulate the rate of translation initiation on the downstream open reading frame. By employing the polymerase chain reaction, we learned that the 5'-terminal 5 nt on the common leader sequence of bovine coronavirus subgenomic mRNAs were heterogeneous and hypervariable throughout early infection in cell culture and that as a persistent infection became established, termini giving rise to a common 33-nt intraleader open reading frame were selected. Since the common leader is derived from the genomic 5' end during transcription, a common focus of origin for the heterogeneity is expected. The intraleader open reading frame was shown by in vitro translation studies to attenuate translation of downstream open reading frames in a cloned bovine coronavirus mRNA molecule. Selection of an intraleader open reading frame resulting in a general attenuation of mRNA translation and a consequent attenuation of virus replication may, therefore, be a mechanism by which coronaviruses and possibly other RNA viruses with a similar transcriptional strategy maintain a persistent infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.