ArticleProceedings of the National Academy of Sciences of the United States of America1993
Multiple motifs regulate the B-cell-specific promoter of the B29 gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin.Molecular therapy. Methods & clinical development · 2023Article
- Autonomous actions of the human growth hormone long-range enhancer.Nucleic acids research · 2015Article
- Identification of a secondary promoter within the human B cell receptor component gene hCD79b.The Journal of biological chemistry · 2013Article
- An RNA-independent linkage of noncoding transcription to long-range enhancer function.Molecular and cellular biology · 2012Article
- Article
- B29 gene silencing in pituitary cells is regulated by its 3' enhancer.Journal of molecular biology · 2006Article
- Bystander gene activation by a locus control region.The EMBO journal · 2004Article
- A conserved sequence upstream of the B29 (Ig beta, CD79b) gene interacts with YY1.Molecular biology reports · 2004Article
- Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines.Oncogene · 2003Article
- Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor.Molecular and cellular biology · 1999Article
- Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.Genes & development · 1998Article
- Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.The EMBO journal · 1997Article
- Silencer elements controlling the B29 (Igbeta) promoter are neither promoter- nor cell-type-specific.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Article
- Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.Molecular and cellular biology · 1996Article
- Activation of transcription by PU.1 requires both acidic and glutamine domains.Molecular and cellular biology · 1996Article
- Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene.Immunogenetics · 1994Article
- The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.Immunogenetics · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The B-cell-specific B29 and mb1 genes code for covalently linked proteins (B29 or Ig beta and mb1 or Ig alpha, respectively) associated with membrane immunoglobulins in the antigen receptor complex on B cells. We have functionally analyzed the upstream region of the B29 gene and have identified a 164-bp region which comprises the minimal promoter responsible for B-cell-specific transcription. Linker scanning mutagenesis of this minimal promoter has established that both the previously identified octamer motif and a DNA motif that binds an unknown protein factor are critical for B29 gene expression in a pre-B-cell and B-cell line. Further mutations showed that binding motifs for Ets, microB/LyF1, and Sp1 also significantly contributed to the overall activity of the minimal B29 promoter. However, the relative contribution of certain motifs to promoter activity was different in a pre-B versus a B-cell line. The microB/LyF1 motif was necessary for full promoter activity in the pre-B cells but was not required in the B cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.