Evidence map›Paper›PMID 8264644›Full record

ArticleMolecular and cellular biology1994

Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.

T Connolly, D Beach

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Review
  5. Article
  6. Article
  7. Article
  8. Molecular mechanisms underlying the mitosis-meiosis decision.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. The G1/S cyclin Cig2p during meiosis in fission yeast.Molecular biology of the cell · 2002
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Two distinct ubiquitin-proteolysis pathways in the fission yeast cell cycle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

T ConnollyHoward Hughes Medical Institute, Cold Spring Harbor Laboratory, NY 11724.
D Beach
Howard Hughes Medical Institute · US

Funding

CONTROL OF CELL DIVISION IN FISSION YEASTR01GM034607 · NIGMS · COLD SPRING HARBOR LABORATORY · PI BEACH, DAVID H. · 1986 to 1993
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NIGMS NIH HHS GM34607
6 · The paper itself

Abstract

In this report, we describe the cloning and characterization of a B-type cyclin, Cig2 from the fission yeast Schizosaccharomyces pombe. The cig2 gene encodes a 45-kDa protein that is most similar to a previously identified B-type cyclin in S. pombe, Cdc13. Deletion of cig2 had no observable effect on cell viability or progression through the cell cycle. Strains carrying the cig2 null allele do, however, exhibit an enhanced ability to undergo conjugation relative to a wild-type strain. The cig2 transcript was found to undergo periodic oscillation during the cell cycle, peaking at the G1/S-phase boundary. We have investigated the relationship between Cig2 and the other B-type cyclins, Cig1 and Cdc13, in the fission yeast. We found that cells carrying disruptions of both the cig1 and cig2 genes contain multiple nuclei with a 1C DNA content, suggesting that they are delayed in progression through the G1 phase of the cell cycle. The phenotype of this double mutant suggests that there is a delay in septum formation, possibly as a result of defective nuclear separation.

Indexed as

Cell Cycle ProteinsSchizosaccharomyces pombe ProteinsAmino Acid SequenceBase SequenceCell CycleCloning, MolecularCyclin BCyclinsDNA, FungalGenes, FungalModels, BiologicalMolecular Sequence DataRNA, MessengerSaccharomyces cerevisiaeSchizosaccharomycesSequence Homology, Amino AcidCell Cycle ProteinsCig2 protein, S pombeCyclin BCyclinsDNA, FungalRNA, MessengerSchizosaccharomyces pombe Proteins

Identifiers

PMID8264644
PMCPMC358425
OpenAlexW1880148029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.