ArticleMolecular and cellular biology1994
Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells.Endocrinology · 2017Article
- Article
- Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.The Journal of clinical investigation · 2015Article
- Transcriptional regulation of mesoderm genes by MEF2D during early Xenopus development.PloS one · 2013Article
- Mef2d acts upstream of muscle identity genes and couples lateral myogenesis to dermomyotome formation in Xenopus laevis.PloS one · 2012Article
- A conserved MRF4 promoter drives transgenic expression in Xenopus embryonic somites and adult muscle.The International journal of developmental biology · 2010Article
- Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.The Journal of clinical investigation · 2007Article
- Metamorphic T3-response genes have specific co-regulator requirements.EMBO reports · 2003Article
- Molecular characterization of the creatine kinases and some historical perspectives.Molecular and cellular biochemistry · 1998Review
- Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD.Molecular and cellular biology · 1997Article
- Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C.Molecular and cellular biology · 1997Article
- Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Multiple steps in the regulation of transcription-factor level and activity.The Biochemical journal · 1996Review
- Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.Molecular and cellular biology · 1996Article
- Expression and activity of serum response factor is required for expression of the muscle-determining factor MyoD in both dividing and differentiating mouse C2C12 myoblasts.Molecular biology of the cell · 1996Article
- Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2.Molecular and cellular biology · 1995Article
- Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis.Molecular and cellular biology · 1995Article
- Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.Molecular and cellular biology · 1995Article
- Nuclear translocation of a maternal CCAAT factor at the start of gastrulation activates Xenopus GATA-2 transcription.The EMBO journal · 1995Article
- E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway.Molecular and cellular biology · 1994Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Members of the MyoD family of helix-loop-helix proteins control expression of the muscle phenotype by regulating the activity of subordinate genes. To investigate processes that control the expression of myogenic factors and regulate the establishment and maintenance of the skeletal muscle phenotype, we have analyzed sequences necessary for transcription of the maternally expressed Xenopus MyoD (XMyoD) gene. A 3.5-kb DNA fragment containing the XMyoDa promoter was expressed in a somite-specific manner in injected frog embryos. The XMyoDa promoter was active in oocytes and cultured muscle cells but not in fibroblasts or nonmuscle cell lines. A 58-bp fragment containing the transcription initiation site, a GC-rich region, and overlapping binding sites for the general transcription factor TFIID and the muscle-specific factor MEF2 was sufficient for muscle-specific transcription. Transcription of the minimal XMyoDa promoter in nonmuscle cells was activated by expression of Xenopus MEF2 (XMEF2) and required binding of both MEF2 and TFIID to the TATA motif. These results demonstrate that the XMyoDa TATA motif is a target for a cell-type-specific regulatory factor and suggests that MEF2 stabilizes and amplifies XMyoDa transcription in mesodermal cells committed to the muscle phenotype.
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