ArticleMolecular and cellular biology1994
Alternative 5' splice site selection induced by heat shock.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Effect of Curcumin on Hepatic mRNA and lncRNA Co-Expression in Heat-Stressed Laying Hens.International journal of molecular sciences · 2024Article
- Drosophila Laser Axotomy Injury Model to Investigate RNA Repair and Splicing in Axon Regeneration.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Transcriptome Analyses Reveal Essential Roles of Alternative Splicing Regulation in Heat-Stressed Holstein Cows.International journal of molecular sciences · 2022Article
- ABA Mediates Plant Development and Abiotic Stress via Alternative Splicing.International journal of molecular sciences · 2022Review
- Analysis of Genomic Alternative Splicing Patterns in Rat under Heat Stress Based on RNA-Seq Data.Genes · 2022Article
- Heat Stress Tolerance GeneFrontiers in microbiology · 2021Article
- Transcriptional response of honey bee (Apis mellifera) to differential nutritional status and Nosema infection.BMC genomics · 2018Article
- Understanding the mechanisms of dormancy in an invasive alien Sycamore lace bug, Corythucha ciliata through transcript and metabolite profiling.Scientific reports · 2017Article
- Alternative splicing in tomato pollen in response to heat stress.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Transcriptomic characterization of cold acclimation in larval zebrafish.BMC genomics · 2013Article
- Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.The Journal of cell biology · 2011Article
- Functional consequences of developmentally regulated alternative splicing.Nature reviews. Genetics · 2011Review
- Divergent mechanisms in generating molecular variations of alphaRYR and betaRYR in turkey skeletal muscle.Journal of muscle research and cell motility · 2007Article
- Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells.Oncogene · 2004Article
- Temperature-dependent splicing of beta-globin pre-mRNA.Nucleic acids research · 2002Article
- Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Cold shock induces the insertion of a cryptic exon in the neurofibromatosis type 1 (NF1) mRNA.Nucleic acids research · 2000Article
- Transcript accumulation and utilization of alternate and non-consensus splice sites in rice granule-bound starch synthase are temperature-sensitive and controlled by a single-nucleotide polymorphism.Plant molecular biology · 1999Article
- Stress and the cell nucleus: dynamics of gene expression and structural reorganization.Gene expression · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse HSP47 gene consists of six exons separated by five introns. Three HSP47 cDNAs differing only in their 5' noncoding regions have been reported. One of these alternatively spliced mRNAs was detected only after heat shock, which caused an alternative 5' splice donor site selection. Other stress inducers, including an amino acid analog and sodium arsenite, had no effect on the alternative splicing. The alternatively spliced mRNA, which was 169 nucleotides longer in the 5' noncoding region compared to mRNA transcribed in non-heat shock conditions, was efficiently translated under heat shock conditions. This novel finding that alternative splicing is caused by artificial treatment like heat shock will provide a useful in vivo model for understanding the exon-intron recognition mechanism as well as heat shock-induced alterations in gene expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.