ArticleMolecular and cellular biology1994
Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 153 citations in OpenAlex.
- Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment.Frontiers in immunology · 2022Article
- Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.International journal of molecular sciences · 2020Review
- Association of single-nucleotide polymorphisms of high-mobility group box 1 with susceptibility and clinicopathological characteristics of uterine cervical neoplasia in Taiwanese women.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The RUNX complex: reaching beyond haematopoiesis into immunity.Immunology · 2015Review
- Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1.The Journal of biological chemistry · 2015Article
- Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Transcription · 2015Review
- Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis.Developmental cell · 2013Article
- c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin.PloS one · 2012Article
- Myb proteins: angels and demons in normal and transformed cells.Frontiers in bioscience (Landmark edition) · 2011Review
- Identification of interacting transcription factors regulating tissue gene expression in human.BMC genomics · 2010Article
- Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells.Nature immunology · 2009Article
- Regulation of cyst wall protein promoters by Myb2 in Giardia lamblia.The Journal of biological chemistry · 2008Article
- EGFR Intron Recombination in Human Gliomas: Inappropriate Diversion of V(D)J Recombination?Current genomics · 2007Article
- ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.Journal of virology · 2007Article
- Article
- Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.Oncogene · 2004Review
- Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.The Journal of experimental medicine · 2001Article
- The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.The Journal of experimental medicine · 2001Article
- Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.Molecular and cellular biology · 2001Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A T-cell-specific transcriptional enhancer lies within the J delta 3-C delta intron of the human T-cell receptor (TCR) delta gene. The 30-bp minimal enhancer element denoted delta E3 carries a core sequence (TGTGGTTT) that binds a T-cell-specific factor, and that is necessary but not sufficient for transcriptional activation. Here we demonstrate that the transcription factor c-Myb regulates TCR delta enhancer activity through a binding site in delta E3 that is adjacent to the core site. Both v-Myb and c-Myb bind specifically to delta E3. The Myb site is necessary for enhancer activity, because a mutation that eliminates Myb binding abolishes transcriptional activation by the delta E3 element and by the 370-bp TCR delta enhancer. Transfection of cells with a c-Myb expression construct upregulates delta E3 enhancer activity, whereas treatment of cells with an antisense c-myb oligonucleotide inhibits delta E3 enhancer activity. Since intact Myb and core sites are both required for delta E3 function, our data argue that c-Myb and core binding factors must cooperate to mediate transcriptional activation through delta E3. Efficient cooperation depends on the relative positioning of the Myb and core sites, since only one of two overlapping Myb sites within delta E3 is functional and alterations of the distance between this site and the core site disrupt enhancer activity. Cooperative regulation by c-Myb and core-binding factors is likely to play an important role in the control of gene expression during T-cell development.
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