ArticleMolecular and cellular biology1994
Chromatin structure and transcriptional activity around the replication forks arrested at the 3' end of the yeast rRNA genes.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Psoralen Crosslinking-Chromatin Endogenous Cleavage Assay to Examine Histone DNA Interactions of Active and Inactive rRNA Genes.Methods in molecular biology (Clifton, N.J.) · 2025Article
- What influences DNA replication rate in budding yeast?PloS one · 2010Article
- Structure and function of ribosomal RNA gene chromatin.Biochemical Society transactions · 2008Review
- Can eukaryotic cells monitor the presence of unreplicated DNA?Cell division · 2007Article
- Replication fork barriers: pausing for a break or stalling for time?EMBO reports · 2007Review
- Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Genes & development · 2005Article
- Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae.Molecular and cellular biology · 2003Article
- Nucleosome positioning at the replication fork.The EMBO journal · 2001Article
- Architecture of the replication fork stalled at the 3' end of yeast ribosomal genes.Molecular and cellular biology · 2000Article
- Ribosomal DNA replication fork barrier and HOT1 recombination hot spot: shared sequences but independent activities.Molecular and cellular biology · 2000Article
- Transcriptional activity and chromatin structure of enhancer-deleted rRNA genes in Saccharomyces cerevisiae.Molecular and cellular biology · 1999Article
- Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA.The EMBO journal · 1997Article
- Transcription in the yeast rRNA gene locus: distribution of the active gene copies and chromatin structure of their flanking regulatory sequences.Molecular and cellular biology · 1995Article
- Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene.Molecular and cellular biology · 1995Article
- Replication fork barriers in the Xenopus rDNA.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Replication intermediates containing forks arrested at the replication fork barrier near the 3' end of the yeast rRNA genes were analyzed at the chromatin level by using in vivo psoralen cross-linking as a probe for chromatin structure. These specific intermediates were purified from preparative two-dimensional agarose gels, and the extent of cross-linking in the different portions of the branched molecules was examined by electron microscopy and by using a psoralen gel retardation assay. The unreplicated section corresponding to the rRNA coding region upstream of the arrested forks appeared mostly heavily cross-linked, characteristic of transcriptionally active rRNA genes devoid of nucleosomes, whereas the replicated daughter strands representing newly synthesized spacer sequences showed a nucleosomal organization typical for bulk chromatin. The failure to detect replication forks arrested at the 3' end of inactive rRNA gene copies and the fact that most DNA encoding rRNA (rDNA) is replicated in the same direction as transcription suggest that replication forks seldom originate from origins of replication located immediately downstream of inactive genes.
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