ArticleMolecular and cellular biology1994
Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 106 citations in OpenAlex.
- Article
- Tyrosines 905 and 915 of gp130 are required for maximum induction of m2 muscarinic acetylcholine receptor and VIP gene transcription by cytokines in neuronal cells.Cellular and molecular neurobiology · 1999Article
- Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.The Biochemical journal · 1998Review
- Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.Genes & development · 1998Article
- Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells.Molecular and cellular biology · 1998Article
- Interleukin-6: structure-function relationships.Protein science : a publication of the Protein Society · 1997Review
- Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Activating mechanism of CNTF and related cytokines.Molecular neurobiology · 1996Review
- Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy.The Biochemical journal · 1996Article
- Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin.Molecular and cellular biology · 1996Article
- Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.The EMBO journal · 1996Article
- IL-6 cytokine family and signal transduction: a model of the cytokine system.Journal of molecular medicine (Berlin, Germany) · 1996Review
- Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The receptor for leukemia inhibitory factor (LIFR), in combination with the signal-transducing subunit for interleukin-6-type cytokine receptors, gp130, and LIF, activates transcription of acute-phase plasma protein genes in human and rat hepatoma cells and the vasoactive intestinal peptide gene in a human neuroblastoma cell line. To identify the regions within the cytoplasmic domain of LIFR that initiate signal transduction independently of gp130, we constructed a chimeric receptor by linking the extracellular domain of the granulocyte colony-stimulating factor receptor (G-CSFR) to the transmembrane and cytoplasmic domain of human LIFR. The function of the chimeric receptor protein in transcriptional activation was assessed by G-CSF-mediated stimulation of cotransfected cytokine-responsive reporter gene constructs in hepatoma and neuroblastoma cells. By using the full-length cytoplasmic domain and mutants with progressive carboxy-terminal deletions, internal deletions, or point mutations, we identified the first 150 amino acid residues of LIFR as the minimal region necessary for signaling. The signaling reaction appears to involve a cooperativity between the first 70-amino-acid region containing the two sequence motifs conserved among hematopoietin receptors (box 1 and box 2) and a critical sequence between residues 141 and 150 (box 3). Analogous analyses of the cytoplasmic domains of G-CSFR and gp130 indicated similar arrangements of functional domains in these receptor subunits and the requirement of a box 3-related motif for signaling.
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