ArticleInfection and immunity1994
Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 250 citations in OpenAlex.
- Kinetics of local and systemic immune responses after vaginal immunization with recombinant cholera toxin B subunit in humans.Clinical and diagnostic laboratory immunology · 2005Trial
- Collection of cervical secretions does not adversely affect Pap smears taken immediately afterward.Clinical and diagnostic laboratory immunology · 1998Trial
- Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain.Infection and immunity · 1996Trial
- Uropathogenic Escherichia coli niche occupancy determines the effects of mucosal vaccine against FimH.Cell reports · 2025Article
- Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice.Cell host & microbe · 2021Article
- Noninvasive measurement of mucosal immunity in a free-ranging baboon population.American journal of primatology · 2020Article
- Staphylococcus aureus-specific IgA antibody in milk suppresses the multiplication of S. aureus in infected bovine udder.BMC veterinary research · 2019Article
- Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity.eLife · 2018Article
- Food-Associated Stress Primes Foodborne Pathogens for the Gastrointestinal Phase of Infection.Frontiers in microbiology · 2018Review
- Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- The gastrointestinal frontier: IgA and viruses.Frontiers in immunology · 2013Review
- Article
- Activation of B cells by a dendritic cell-targeted oral vaccine.Current pharmaceutical biotechnology · 2013Review
- Prime-boost approaches to tuberculosis vaccine development.Expert review of vaccines · 2012Review
- Consumption of rice bran increases mucosal immunoglobulin A concentrations and numbers of intestinal Lactobacillus spp.Journal of medicinal food · 2012Article
- Cell-mediated and humoral immune responses in pigs following primary and challenge-exposure to Lawsonia intracellularis.Veterinary research · 2012Article
- Enhancing oral vaccine potency by targeting intestinal M cells.PLoS pathogens · 2010Review
- Primary activation of antigen-specific naive CD4+ and CD8+ T cells following intranasal vaccination with recombinant bacteria.Infection and immunity · 2008Article
- Intravaginal immunization of mice with recombinant Salmonella enterica serovar Typhimurium expressing human papillomavirus type 16 antigens as a potential route of vaccination against cervical cancer.Infection and immunity · 2008Article
- Intranasal immunization with Gal-inhibitable lectin plus an adjuvant of CpG oligodeoxynucleotides protects against Entamoeba histolytica challenge.Infection and immunity · 2007Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In order study patterns of local antibody responses following mucosal immunization of mice via different routes, a method for collection of secretions directly from mucosal surfaces was developed. Mice were immunized on days 0, 10, 17, and 24 by administration of cholera toxin into the oral cavity, stomach, colon-rectum, or vagina. At sacrifice on day 32, absorbent wicks were placed in the oral cavity and, via an applicator tube, into the vagina and distal colon-rectum and along the entire small intestine after flushing of luminal contents. Protein was quantitatively extracted from wicks, and specific anti-cholera toxin immunoglobulin A (IgA) and IgG were measured by enzyme-linked immunosorbent assay. Concentrations of specific IgA in secretions at various mucosal sites were dramatically influenced by the route of immunization. Oral immunization effectively induced IgA in saliva, and the intragastric route was optimal for induction of IgA in the small intestine. High levels of specific IgA appeared on the colonic-rectal mucosal surface only after rectal delivery of antigen. Oral, gastric, and rectal immunizations also produced distant responses in the vagina. Following vaginal immunization, however, neither local nor distant IgA responses were detected. These results suggest that vaccines intended for protection of colonic-rectal and vaginal mucosal surfaces might best be administered by the rectal route.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.