ArticleImmunology1993
Presentation of peptides and proteins by intestinal epithelial cells.
Article in Immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Mapping the New World of Necrotizing Enterocolitis (NEC): Review and Opinion.The e-journal of neonatology research · 2012Article
- Postnatal maturation of rat small intestinal brush border membranes correlates with increase in food protein binding capacity.Digestive diseases and sciences · 1998Article
- Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.The Journal of clinical investigation · 1997Article
- A comparison of the antigen-presenting capabilities of class II MHC-expressing human lung epithelial and endothelial cells.Immunology · 1997Article
- Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells.Clinical and experimental immunology · 1995Article
- Intestinal intraepithelial lymphocytes: the plot thickens.The Journal of experimental medicine · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine intestinal epithelial cells (IEC) constitutively express major histocompatibility complex (MHC) class II molecules, which enable them to present foreign antigens to T cells in vitro. In this study we have compared the ability of freshly isolated IEC and spleen adherent cells to present both protein and peptide antigens to T cells in vitro. Consistently IEC were unable to present protein but could readily present immunogenic peptides in an MHC-dependent fashion to stimulate lymphokine release from T cells. Consistent with their inability to process protein antigens, IEC were also unable to present a synthetic peptide which requires intracellular processing, whereas spleen antigen-presenting cells (APC) could readily present the same peptide. These findings indicate that IEC may lack the necessary intracellular machinery to process exogenous antigens but they raise the possibility that IEC may play an important immunological role in vivo by presenting processed peptides to T cells.
Indexed as
Identifiers
8262549PMC1422197What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.