ArticleThe EMBO journal1993
Critical intracellular Ca2+ concentration for all-or-none Ca2+ spiking in single smooth muscle cells.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 88 citations in OpenAlex.
- Vascular tone and Ca(2+) signaling in murine cremaster muscle arterioles in vivo.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Inositol trisphosphate receptors in smooth muscle cells.American journal of physiology. Heart and circulatory physiology · 2012Review
- Agonist-evoked Ca(2+) wave progression requires Ca(2+) and IP(3).Journal of cellular physiology · 2010Article
- Spatiotemporal dynamics of Ca2+ signaling and its physiological roles.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Nerve-evoked purinergic signalling suppresses action potentials, Ca2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle.The Journal of physiology · 2009Article
- Cytosolic inositol 1,4,5-trisphosphate dynamics during intracellular calcium oscillations in living cells.The Journal of cell biology · 2006Article
- Ca2+ shuttling between endoplasmic reticulum and mitochondria underlying Ca2+ oscillations.EMBO reports · 2006Article
- Ca2+ -induced Ca2+ release through localized Ca2+ uncaging in smooth muscle.The Journal of general physiology · 2006Article
- IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells.The Journal of physiology · 2005Article
- Elementary purinergic Ca2+ transients evoked by nerve stimulation in rat urinary bladder smooth muscle.The Journal of physiology · 2005Article
- Family affairs of intracellular Ca(2+)-release channels.The Journal of physiology · 2002Article
- The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells.British journal of pharmacology · 2001Article
- Ca(2+)-sensor region of IP(3) receptor controls intracellular Ca(2+) signaling.The EMBO journal · 2001Article
- Role of elementary Ca(2+) puffs in generating repetitive Ca(2+) oscillations.The EMBO journal · 2001Article
- Ca(2+) signals mediated by Ins(1,4,5)P(3)-gated channels in rat ureteric myocytes.The Biochemical journal · 2000Article
- Kinetic control of multiple forms of Ca(2+) spikes by inositol trisphosphate in pancreatic acinar cells.The Journal of cell biology · 1999Article
- Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes.The EMBO journal · 1999Article
- Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra.The Journal of physiology · 1999Article
- Cyclic GMP-dependent but G-kinase-independent inhibition of Ca2+-dependent Cl- currents by NO donors in cat tracheal smooth muscle.The Journal of physiology · 1998Article
- The effects of free [Ca2+] on the cytosolic face of the inositol (1,4,5)-trisphosphate receptor at the single channel level.The Biochemical journal · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotransmitters induce contractions of smooth muscle cells initially by mobilizing Ca2+ from intracellular Ca2+ stores through inositol 1,4,5-trisphosphate (InsP3) receptors. Here we studied roles of the molecules involved in Ca2+ mobilization in single smooth muscle cells. A slow rise in cytoplasmic Ca2+ ([Ca2+]i) in agonist-stimulated smooth muscle cells was followed by a wave of rapid regenerative Ca2+ release as the local [Ca2+]i reached a critical concentration of approximately 160 nM. Neither feedback regulation of phospholipase C nor caffeine-sensitive Ca(2+)-induced Ca2+ release was found to be required in the regenerative Ca2+ release. These results indicate that Ca(2+)-dependent feedback control of InsP3-induced Ca2+ release plays a dominant role in the generation of the regenerative Ca2+ release. The resulting Ca2+ release in a whole cell was an all-or-none event, i.e. constant peak [Ca2+]i was attained with agonist concentrations above the threshold value. This finding suggests a possible digital mode involved in the neural control of smooth muscle contraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.