ArticleThe EMBO journal1993
A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.
Article in The EMBO journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 74 citations in OpenAlex.
- ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling.The Journal of biological chemistry · 2011Article
- The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling.Molecular and cellular biology · 2005Article
- The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes.Molecular and cellular biology · 2001Article
- Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor.Molecular and cellular biology · 2001Article
- Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice.British journal of pharmacology · 1999Article
- Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression.Molecular and cellular biology · 1999Article
- A low-affinity serum response element allows other transcription factors to activate inducible gene expression in cardiac myocytes.Molecular and cellular biology · 1999Article
- An A/G-rich motif in the rat fibroblast growth factor-2 gene confers enhancer activity on a heterologous promoter in neonatal rat cardiac myocytes.Molecular and cellular biochemistry · 1998Article
- The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.The EMBO journal · 1997Article
- The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium.Molecular and cellular biology · 1996Article
- Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: implications for cardiac hypertrophy.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.The Journal of clinical investigation · 1995Article
- The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types.British journal of pharmacology · 1995Article
- A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
alpha 1-Adrenergic agonists and antagonists constitute an important class of therapeutic agents commonly used for the treatment of various cardiovascular diseases like hypertension, congestive heart failure and supraventricular tachycardia. At the heart level, activation of alpha 1-adrenergic receptors is associated with marked morphological and genetic changes. These include enhancement of contractility, myocardial growth (hypertrophy) and release of the heart major secretory product, atrial natriuretic factor (ANF). However, the signal transduction pathways which link extracellular activation of the receptors to cellular and genetic changes are not well understood. Using primary cardiocyte cultures from neonate rat hearts, an alpha 1-adrenergic regulatory sequence has been identified in the 5' flanking region of the ANF gene. This sequence, which is necessary and sufficient for transcriptional activation in response to the alpha 1-specific agonist phenylephrine, interacts with novel zinc-dependent proteins which are induced by alpha 1-adrenergic stimulation. Consistent with a conserved regulatory mechanism, the alpha 1 response element is highly conserved between rodent, bovine and human ANF genes, and is also present in the promoter region of other alpha 1-responsive cardiac genes. The identification of a nuclear pathway for alpha 1-receptor signaling will be useful for elucidating the intracellular effectors of alpha 1-adrenergic receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.