ArticleAntimicrobial agents and chemotherapy1993
Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.
Article in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Effect of bismuth subsalicylate on ciprofloxacin bioavailability.Antimicrobial agents and chemotherapy · 1994Trial
- A comparative application of spectrophotometric and spectrofluorimetric methods to estimate levofloxacin-DNA and ofloxacin-DNA interactions.Journal of fluorescence · 2025Article
- Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline.Pharmaceutics · 2023Article
- Effects of Magnesium, Calcium, and Aluminum Chelation on Fluoroquinolone Absorption Rate and Bioavailability: A Computational Study.Pharmaceutics · 2021Article
- Sustainable waste management and recycling of Zn-Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial.RSC advances · 2020Article
- Clinical Drug-Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives.European journal of drug metabolism and pharmacokinetics · 2016Review
- A case study of in silico modelling of ciprofloxacin hydrochloride/metallic compound interactions.AAPS PharmSciTech · 2014Article
- Interactions between new quinolone antibacterials and diagnostic drug containing manganese.European journal of drug metabolism and pharmacokinetics · 2013Article
- The interaction between levofloxacine hydrochloride and DNA mediated by Cu2+.Journal of fluorescence · 2004Article
- Review
- Review
- The new fluoroquinolones: A critical review.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 1999Article
- Levofloxacin. Its use in infections of the respiratory tract, skin, soft tissues and urinary tract.Drugs · 1998Review
- Absorption of ofloxacin isomers in the rat small intestine.Antimicrobial agents and chemotherapy · 1997Article
- The clinical pharmacokinetics of levofloxacin.Clinical pharmacokinetics · 1997Review
- Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains.Antimicrobial agents and chemotherapy · 1995Article
- Susceptibility to levofloxacin predicted from in vitro susceptibility testing results obtained with ciprofloxacin and with ofloxacin.Journal of clinical microbiology · 1995Article
- Drug interactions with antacids. Mechanisms and clinical significance.Drug safety · 1994Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms of reduction in absorption of levofloxacin (LVFX) by coadministration of aluminum hydroxide were studied. The partition coefficient of LVFX (0.1 mM) between chloroform and phosphate buffer (pH 5.0) was reduced by 60 to 70% with the addition of metal ions such as Cu2+, Al3+, and Fe2+ (0.8 mM), which indicated the formation of LVFX-metal ion chelates. However, there was no significant difference in absorption from rat intestine between the synthetic LVFX-Al3+ (1:1) chelate (6.75 mM) and LVFX (6.75 mM) in an in situ recirculation experiment. On the other hand, Al(NO3)3 (1.5 mM) significantly inhibited the absorption of LVFX (1.5 mM) by 20% of the control in the in situ ligated loop experiment, in which partial precipitation of aluminum hydroxide was observed in the dosing solution. Data for adsorption of LVFX and ofloxacin (OFLX) from aqueous solution by aluminum hydroxide were shown to fit Langmuir plots, and the adsorptive capacities (rmax) and the K values were 7.0 mg/g and 1.77 x 10(4) M-1 for LVFX and 7.4 mg/g and 1.42 x 10(4) M-1 for OFLX, respectively. The rate of adsorption of several quinolones (50 microM) onto aluminum hydroxide (2.5 mg/ml) followed the order norfloxacin (NFLX) (72.0%) > enoxacin (ENX) (61.0%) > OFLX (47.2%) approximately LVFX (48.1%). The elution rate of adsorbed quinolones with water followed the rank order LVFX (17.9%) approximately OFLX (20.9%) approximately ENX (18.3%) > NFLX (11.9%). These results strongly suggest that adsorption of quinolones by aluminum hydroxide reprecipitated in the small intestine would play an important role in the reduced bioavailability of quinolones after coadministration with aluminum-containing antacids.
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