ArticleThe American journal of pathology1993
Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 130 citations in OpenAlex.
- Description of the Hamburg Alexander Leukodystrophy Cohort-Insights into Practical Classification and the Care Situation.Journal of clinical medicine · 2025Article
- Establishment and Use of Primary Cultured Astrocytes from Alexander Disease Model Mice.International journal of molecular sciences · 2024Article
- Article
- Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways.Biology · 2021Review
- Cell-free synthesis of functionally active HSPB5.Cell stress & chaperones · 2020Article
- Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation.Translational neurodegeneration · 2019Article
- Small heat shock protein speciation: novel non-canonical 44 kDa HspB5-related protein species in rat and human tissues.Cell stress & chaperones · 2018Article
- Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differentiation into Mature Oligodendrocytes.Frontiers in neurology · 2017Article
- Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma.PloS one · 2017Article
- HspB5/αB-crystallin increases dendritic complexity and protects the dendritic arbor during heat shock in cultured rat hippocampal neurons.Cellular and molecular life sciences : CMLS · 2016Article
- Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes.Acta neuropathologica communications · 2016Article
- Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.Progress in retinal and eye research · 2016Review
- Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis.Cellular and molecular life sciences : CMLS · 2015Review
- Small heat-shock proteins: important players in regulating cellular proteostasis.Cellular and molecular life sciences : CMLS · 2015Review
- Comparative study of Hsp27, GSK3β, Wnt1 and PRDX3 in Hirschsprung's disease.International journal of experimental pathology · 2014Article
- Crystallins in retinal ganglion cell survival and regeneration.Molecular neurobiology · 2013Review
- Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.ASN neuro · 2013Article
- Crystallins are regulated biomarkers for monitoring topical therapy of glaucomatous optic neuropathy.PloS one · 2013Article
- Charcot-Marie-Tooth disease and intracellular traffic.Progress in neurobiology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Alexander disease is a leukodystrophy characterized by the presence of numerous Rosenthal fibers, inclusion bodies in astrocytes. A major component of Rosenthal fibers is alpha B-crystallin, some of which is ubiquitinated. In this report, we show that Alexander central nervous system (CNS) tissues contain elevated messenger RNA and protein levels of both alpha B-crystallin and the related small heat shock protein, hsp27, and that Rosenthal fibers contain hsp27. The alpha B-crystallin and hsp27 polypeptide isoform patterns of Alexander disease CNS are also distinct from those of control samples, suggesting that postranslational modifications may be involved in Rosenthal fiber formation. We advance the hypothesis that Rosenthal fibers may be regarded as stress protein inclusions formed in astrocytes as part of a chronic stress response to an as yet unknown stimulus in the CNS of Alexander patients.
Indexed as
Identifiers
8256860PMC1887278W287231401What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.