ReviewThe American journal of pathology1993
The SCID mouse: relevance as an animal model system for studying human disease.
Review in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- 3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber.Journal of biomedical optics · 2011Article
- Animal models of breast cancer for the study of pathogenesis and therapeutic insights.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
- Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1.Virology journal · 2005Article
- Animal models of acute myelogenous leukaemia - development, application and future perspectives.Leukemia · 2005Review
- Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis.The American journal of pathology · 2002Article
- Transfer of the feline erythropoietin gene to cats using a recombinant adeno-associated virus vector.Gene therapy · 2000Article
- Immunohistochemical and ultrastructural evidence for myelopoiesis in the scid/scid mouse thymus.The Histochemical journal · 1999Article
- Ovine neuronal ceroid lipofuscinosis: a large animal model syntenic with the human neuronal ceroid lipofuscinosis variant CLN6.Journal of medical genetics · 1998Article
- Cell-cycle regulation of mammalian DNA double-strand-break repair.American journal of human genetics · 1997Review
- [Pathogenesis of rheumatoid arthritis].Medizinische Klinik (Munich, Germany : 1983) · 1997Review
- A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Technical considerations for studying cancer metastasis in vivo.Clinical & experimental metastasis · 1997Review
- Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle.Molecular and cellular biology · 1997Article
- A human xenograft model for testing early events of epithelial neoplastic invasion.International journal of oncology · 1997Article
- Animal models of human-derived cancer vaccines.Cell biophysics · 1995Review
- Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model.The American journal of pathology · 1995Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The simultaneous description some 5 years ago of two methods for the partial reconstitution of a human immune system in severe combined immune-deficient (SCID) mice (collectively, human:SCID mice) was met with great enthusiasm. At the time, it was hoped that human:SCID mice would provide experimental animal model systems for studying human disease and the human immune system. Many of these hopes have been borne out. Importantly, the experimental results obtained from these chimeric human/animal studies appear to be relevant to human disease and immune function. In spite of these glowing achievements, the SCID mouse may not represent the optimal experimental system with which to address these questions. The incomplete penetrance ("leakiness") of the scid mutation and the recent discovery that the mutation is not lymphoid specific, but rather affects a general DNA repair pathway, will only serve to complicate the interpretation of already complex biological interactions. Recently other immune-deficient mice have been described that appear to overcome one or both of these problems and thus these mice could represent improved hosts for the adaptive transfer of a human immune system. The current status of the SCID mouse in light of these new findings is discussed.
Indexed as
Identifiers
8256843PMC1887268What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.