ArticleNucleic acids research1993
Functional redundancy of octamer elements in the mouse mammary tumor virus promoter.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Architecture of the sporulation-specific Cdc14 promoter from the oomycete Phytophthora infestans.Eukaryotic cell · 2007Article
- Mutational and functional analysis of the C-terminal region of the C3H mouse mammary tumor virus superantigen.Journal of virology · 1998Article
- RNA polymerase II transcription complex assembly in nuclear extracts.Gene expression · 1998Article
- The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression.Molecular and cellular biology · 1997Article
- An eye imaginal disc-specific transcriptional enhancer in the long terminal repeat of the tom retrotransposon is responsible for eye morphology mutations of Drosophila ananassae.Molecular & general genetics : MGG · 1996Article
- Stimulation of basal transcription from the mouse mammary tumor virus promoter by Oct proteins.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The promoter of mouse mammary tumor virus contains three overlapping sequence elements related to the octamer consensus (ATGCAAAT) that are largely contained within two 10 bp direct repeats (CTTATGTAAA) separated by a 2 bp spacer between 60 and 39 relative to the start of transcription. Gel electrophoresis mobility shift competition assays demonstrate that the most distal of these octamer-related elements is recognized by a protein that also binds to the most proximal element, while the central octamer-related element is not efficiently recognized. Transient transfection assays with altered promoters reveal that the portion of the 10 bp repeat that is not related to the octamer consensus appears not to be important for transcription. The distal and proximal octamer-related elements are, at least to some extent, functionally redundant. Complete deletion of one element has little or no effect on promoter activity so long as certain spacing constraints among remaining promoter elements are maintained. Systematic variation of such spacing reveals a cyclic effect on promoter activity corresponding to the periodicity of Bform DNA, suggesting functional interactions between proteins bound to adjacent sites.
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