ArticleNucleic acids research1993
Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia.Cancer medicine · 2022Article
- Schnurri-3 regulates BMP9-induced osteogenic differentiation and angiogenesis of human amniotic mesenchymal stem cells through Runx2 and VEGF.Cell death & disease · 2020Article
- Immune-related functions of the Hivep gene family in East African cichlid fishes.G3 (Bethesda, Md.) · 2013Article
- Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.Molecular immunology · 2013Article
- Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.The Journal of biological chemistry · 2011Article
- Article
- Signaling networks that control the lineage commitment and differentiation of bone cells.Critical reviews in eukaryotic gene expression · 2009Review
- Signaling and transcriptional regulation in osteoblast commitment and differentiation.Frontiers in bioscience : a journal and virtual library · 2007Review
- Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.Gene expression · 2007Article
- Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.BMC neuroscience · 2006Article
- Inhibition of NF-kappaB by ZAS3, a zinc-finger protein that also binds to the kappaB motif.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The kappa B transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection amplification binding study.BMC immunology · 2002Article
- ZAS: C2H2 zinc finger proteins involved in growth and development.Gene expression · 2002Review
- Stereochemical basis of DNA recognition by Zn fingers.Nucleic acids research · 1994Article
- The V(D)J recombination signal sequence and kappa B binding protein Rc binds DNA as dimers and forms multimeric structures with its DNA ligands.Nucleic acids research · 1994Article
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Authors and funding
6 authors.
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Abstract
The somatic V(D)J recombination for the assembly of the Ig and TCR genes is mediated by the recombination signal sequences (Rss) and the V(D)J recombinase. A cDNA clone was isolated from a lambda gt11 expression library made from mouse thymocyte poly(A)+ RNA, using the Rss as a ligand. The deduced amino acid sequence of the putative protein, designated Recognition component (Rc), reveals a pair of Cys2-His2 zinc fingers followed by a Glu- and Asp-rich acidic domain. In addition, there are five copies of the Ser/Thr-Pro-X-Arg/Lys sequence, which are putative DNA binding units. The zinc finger-acidic domain structures present in Rc are also found in several enhancer binding proteins, such as those for the kappa B motif of the Ig kappa light chain enhancer or related sequences. Bacterial fusion proteins for Rc bind preferentially to the Rss heptamer and to the kappa B motif. The dual affinities of Rc for the Rss heptamer and the kappa B motif suggest a possible link between Ig transcription and somatic recombination. The formation of multiple 'gel-shifted' DNA-protein complexes for Rc and its DNA ligand suggests that these complexes tend to multimerize.
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