ArticleThe Journal of physiology1993
The effects of inhibitors of sarcoplasmic reticulum function on the systolic Ca2+ transient in rat ventricular myocytes.
Article in The Journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Generation of myocyte agonal CaScientific reports · 2023Article
- Molecular link between circadian clocks and cardiac function: a network of core clock, slave clock, and effectors.Current opinion in pharmacology · 2021Review
- The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications.Circulation research · 2020Review
- Ups and downs of calcium in the heart.The Journal of physiology · 2018Article
- Plasma membrane CaThe Journal of physiology · 2017Article
- Systolic [CaThe Journal of physiology · 2017Article
- Calcium and Excitation-Contraction Coupling in the Heart.Circulation research · 2017Review
- Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.The Journal of physiology · 2016Article
- The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca2+ handling in rat ventricular myocytes.Cell calcium · 2015Article
- Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes.Cardiovascular research · 2014Article
- Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions.Cardiovascular research · 2014Article
- Electromechanical and atrial and ventricular antiarrhythmic actions of CIJ-3-2F, a novel benzyl-furoquinoline vasodilator in rat heart.British journal of pharmacology · 2014Article
- Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study.Theoretical biology & medical modelling · 2013Article
- Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers.Biophysical journal · 2012Article
- Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure.Biophysical journal · 2007Article
- A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.Biophysical journal · 2004Article
- Distinct load dependence of relaxation rate and diastolic function in Oryctolagus cuniculus and Ratus norvegicus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2003Article
- Time-dependent changes of the susceptibility of cardiac contractile function to hypoxia-reoxygenation after myocardial infarction in rats.Molecular and cellular biochemistry · 2002Article
- Calcium handling by the sarcoplasmic reticulum during oscillatory contractions of skinned skeletal muscle fibres.Journal of muscle research and cell motility · 1998Article
- Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol.The Journal of general physiology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. The effects of thapsigargin, ryanodine and caffeine were examined on systolic Ca2+ transients in indo-1-loaded rat ventricular myocytes. 2. Thapsigargin (1-10 microM) decreased the magnitude of the Ca2+ transient. This was accompanied by a decrease of the rate constant of decay of the transient. 3. Ryanodine (1-10 microM) decreased the magnitude of the Ca2+ transient. Initially there was no change in the rate of decay but further reduction of the magnitude was accompanied by a slowing. 4. Caffeine (0.5-10 mM) decreased the magnitude of the Ca2+ transient and its rate of decay. These effects were graded with caffeine concentration. 5. For a given submaximal reduction of the magnitude of the Ca2+ transient, the effect on the rate of decay was greatest for thapsigargin, least for ryanodine and intermediate for caffeine. 6. The above data are reproduced by a model in which all three agents decrease the magnitude of the Ca2+ transient by decreasing the calcium content of the sarcoplasmic reticulum (SR) (thapsigargin by inhibiting the Ca2+ pump and ryanodine and caffeine by increasing the leak of Ca2+ from the SR). The decreased contribution of the SR will thereby slow relaxation. The fact that thapsigargin inhibits the SR Ca2+ pump accounts for the observation that, for a given decrease of amplitude, it has more effect than the other agents on the rate of decay. The difference between caffeine and ryanodine is suggested to arise because caffeine potentiates Ca2+ release from the SR and thereby attenuates the effect of the decreased SR calcium content on the magnitude of the Ca2+ transient.
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