ArticleThe Journal of physiology1993
Characterization of an outward potassium current in canine jejunal circular smooth muscle and its activation by fenamates.
Article in The Journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Nonsteroidal Anti-Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies.ChemMedChem · 2025Review
- Inhibitors of connexin and pannexin channels as potential therapeutics.Pharmacology & therapeutics · 2017Review
- Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Pulmonary circulation · 2015Review
- Real-time measurement of biomagnetic vector fields in functional syncytium using amorphous metal.Scientific reports · 2015Article
- Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.Neurochemical research · 2014Article
- Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.American journal of physiology. Cell physiology · 2012Article
- Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1.Biochemical and biophysical research communications · 2012Article
- Ano1 as a regulator of proliferation.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Membrane current oscillations in descending vasa recta pericytes.American journal of physiology. Renal physiology · 2008Article
- P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Mefenamic acid as a novel activator of L-type voltage-dependent Ca2+ channels in smooth muscle cells from pig proximal urethra.British journal of pharmacology · 2005Article
- Characteristics and a functional implication of Ca(2+)-activated K(+) current in mouse aortic endothelial cells.Pflugers Archiv : European journal of physiology · 2004Article
- Multiple effects of mefenamic acid on K(+) currents in smooth muscle cells from pig proximal urethra.British journal of pharmacology · 2003Article
- Heterogeneous expression of transient outward currents in smooth muscle cells of the mouse small intestine.The Journal of physiology · 2002Article
- Multiple action sites of flufenamate on ion transport across the rat distal colon.British journal of pharmacology · 2000Article
- The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs.Gut · 1998Article
- Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid.Pflugers Archiv : European journal of physiology · 1996Article
- Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids.Biophysical journal · 1994Article
- Contribution of chloride conductance increase to slow EPSC and tachykinin current in guinea-pig myenteric neurones.The Journal of physiology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
1. A perforated patch clamp technique was used to study an outward potassium current in freshly dissociated circular smooth muscle cells of the canine jejunum. 2. A voltage-dependent outward current was identified which was highly potassium selective, weakly holding voltage sensitive, increased its open probability at -65 mV, and reached unit open probability at +5 mV. 3. Quinidine (0.1-1 mM) and tetraethylammonium ion (TEA) (10-50 mM), blocked the potassium current in a dose-dependent manner. Blockade of the outward potassium current was accompanied by membrane depolarization which reversed on removal of the blocker from the bathing solution. 4. Mefenamic and flufenamic acids, non-steroidal anti-inflammatory agents in the fenamate group, were potent activators of the current. Activation was accompanied by hyperpolarization of the membrane with a mean shift in the membrane voltage of 22 mV. 5. It was concluded that the outward potassium current is a major regulator of the resting membrane voltage in isolated circular smooth muscle cells of the canine jejunum. Fenamates activated this current with potentially profound effects on cellular excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.