ArticleThe Journal of physiology1993
Action of histamine on single smooth muscle cells dispersed from the rabbit pulmonary artery.
Article in The Journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Pulmonary circulation · 2015Review
- Cl⁻ channels in smooth muscle cells.Pflugers Archiv : European journal of physiology · 2014Review
- Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling.Comprehensive Physiology · 2011Review
- Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels.Pulmonary circulation · 2011Article
- Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor.British journal of pharmacology · 2010Article
- Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium.British journal of pharmacology · 2009Article
- Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.American journal of physiology. Cell physiology · 2006Article
- Multiple conductance states of single Ca2+-activated Cl- channels in rabbit pulmonary artery smooth muscle cells.The Journal of physiology · 2003Article
- Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells.The Journal of physiology · 2002Article
- Cell-to-cell communication via nitric oxide modulation of oscillatory Cl(-) currents in rat intact cerebral arterioles.The Journal of physiology · 2001Article
- Signalling pathway for histamine activation of non-selective cation channels in equine tracheal myocytes.The Journal of physiology · 2000Article
- Chloride channel blockers inhibit myogenic tone in rat cerebral arteries.The Journal of physiology · 1997Article
- Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein.British journal of pharmacology · 1996Article
- Caffeine- and histamine-induced oscillations of K(Ca) current in single smooth muscle cells of rabbit cerebral artery.Pflugers Archiv : European journal of physiology · 1995Article
- Biophysical properties of Ca(2+)- and Mg-ATP-activated K+ channels in pulmonary arterial smooth muscle cells isolated from the rat.Pflugers Archiv : European journal of physiology · 1994Article
- Synergistic action of histamine and adenosine triphosphate on the response to noradrenaline in rabbit pulmonary artery smooth muscle cells.Pflugers Archiv : European journal of physiology · 1994Article
- Properties of spontaneous inward currents in rabbit pulmonary artery smooth muscle cells.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. The effects of histamine, noradrenaline and caffeine were studied in freshly dispersed smooth muscle cells from the rabbit pulmonary artery using the perforated patch technique. 2. In potassium-containing solutions at a holding potential of -50 mV all three agents evoked net inward and outward currents. At 0 mV only an outward current was observed and this response was not produced in potassium-free conditions. 3. In K(+)-free solutions the reversal potential (Er) of the inward current was dependent upon the transmembrane anion gradient but not on the cation gradient. Thus all three agents produced an increase in potassium and chloride conductance. 4. Bath-applied histamine evoked repetitive potassium and chloride currents in many cells. Bath-applied noradrenaline and caffeine, to a lesser extent, also caused repetitive currents but the brief ionophoretic application of noradrenaline never produced oscillations in membrane current. 5. Histamine reduced or abolished the amplitude of spontaneous transient potassium and chloride currents. 6. Histamine-induced currents were blocked by caffeine (10 mM) but could be recorded in Ca(2+)-free bathing solutions. 7. It is concluded that in the rabbit pulmonary artery histamine evokes single and oscillatory membrane potassium and chloride currents which are mediated by the release of calcium from intracellular caffeine-sensitive stores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.