ArticleThe Journal of cell biology1993
Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages.Journal of virology · 2011Article
- Sex- and depot-dependent differences in adipogenesis in normal-weight humans.Obesity (Silver Spring, Md.) · 2010Article
- Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.Molecular biology of the cell · 2009Article
- Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway.The Journal of cell biology · 2008Article
- Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.The EMBO journal · 2007Article
- Plasma membrane sterol distribution resembles the surface topography of living cells.Molecular biology of the cell · 2007Article
- Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia.The Journal of clinical investigation · 2007Article
- Transferrin-oligomers as potential carriers in anticancer drug delivery.Pharmaceutical research · 2004Article
- Intracellular cholesterol and phospholipid trafficking: comparable mechanisms in macrophages and neuronal cells.Neurochemical research · 2001Review
- LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice.The Journal of clinical investigation · 2001Article
- Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: studies in C57BL/6 apolipoprotein E knockout mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Sphingomyelinase treatment induces ATP-independent endocytosis.The Journal of cell biology · 1998Article
- Simultaneous labeling of lipoprotein intracellular trafficking in pigeon monocyte-derived macrophages.The American journal of pathology · 1997Article
- Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment.The Journal of cell biology · 1995Article
- Autocrine motility factor receptor is a marker for a distinct membranous tubular organelle.The Journal of cell biology · 1995Article
- Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
beta-very low density lipoprotein (VLDL) is a large lipoprotein with multiple apoprotein E (apoE) molecules that bind to the LDL receptors on mouse macrophages. Even though they bind to the same receptor, the endocytic processing of beta-VLDL differs from low density lipoprotein (LDL). LDL is rapidly delivered to perinuclear lysosomes and degraded, but much of the beta-VLDL is retained in peripheral compartments for several minutes. We have investigated the properties of these peripheral compartments. Measurement of the pH was made using FITC-phosphatidylethanolamine incorporated into the beta-VLDL, and we found that the peripheral compartments were near neutral in pH. These peripheral, beta-VLDL containing compartments were poorly accessible to antibodies, but a low molecular weight fluorescence quencher (trypan blue) entered the compartments within a few seconds. Intermediate voltage EM of cells labeled with colloidal-gold-beta-VLDL revealed that the peripheral compartments are tubular, surface-connected invaginations. Kinetic studies with fluorescent beta-VLDL showed that the compartments become fully sealed with a half-time of 6 min, and the beta-VLDL is then delivered rapidly to perinuclear lysosomes. By monitoring fluorescence energy transfer between lipid analogs incorporated into the beta-VLDL, some processing of the lipoprotein in the peripheral tubular compartments is demonstrated. The novel mode of uptake of beta-VLDL may account for the high cholesterol ester accumulation induced by this lipoprotein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.