ArticleClinical and experimental immunology1976
Schistosoma mansoni in baboons. Antibody-dependent cell-mediated damage to 51Cr-labelled schistosomula.
Article in Clinical and experimental immunology, 1976. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 40 citations in OpenAlex.
- Glycoconjugates in host-helminth interactions.Frontiers in immunology · 2013Review
- Article
- IgE-dependent cellular adhesion and cytotoxicity to Litomosoides carinii microfilariae--nature of effector cells.Clinical and experimental immunology · 1982Article
- The modulation of specific and non-specific cell-mediated immunity in baboons (Papio anubis) infected with Schistosoma mansoni.Immunology · 1982Article
- Cytotoxicity of human and baboon mononuclear phagocytes against schistosomula in vitro: induction by immune complexes containing IgE and Schistosoma mansoni antigens.Clinical and experimental immunology · 1978Article
- Kidney lesions in baboons infected with Schistosoma mansoni.Clinical and experimental immunology · 1977Article
- Eosinophilopoietin. A circulating low molecular weight peptide-like substance which stimulates the production of eosinophils in mice.The Journal of clinical investigation · 1977Article
- Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils.The Journal of experimental medicine · 1977Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A technique is described for estimating cell-mediated damage to the larval stages of Schistosoma mansoni that occur in the mamalian host (schistosomula), by measuring release of 51Cr from labelled organisms. This technique, although widely used for assaying cytotoxicity to single cell suspensions or monolayers, has not previously been applied to a multicellular parasite. It is more objective than microscopical assays, and allows the processing of larger numbers of samples. The new method has been used for the detection and quantification of cell-dependent cytotoxic antibodies in infected baboons. The effector cell in normal baboon peripheral blood, as in man, is associated with a neutrophil- and eosinophil-enriched fraction. Cytotoxic antibodies appear in the serum about 4 weeks after a primary infection, rising to a peak at 7-10 weeks, and then declining. In some animals, a second rise towards 30 weeks was observed. There were no consistent differences between groups of baboons exposed to 1000 cercariae, 200 cercariae, and 200 cercariae administered at each of five monthly intervals. The possible relationship between cell-dependent cytotoxic antibodies and resistance to reinfection in infected animals is discussed.
Indexed as
Identifiers
825338PMC1541391W40085659What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.