ArticleClinical and experimental immunology1993
Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes: clues to the mechanism.
Article in Clinical and experimental immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Targeting integrin pathways: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2023Review
- The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβCell death and differentiation · 2022Article
- The impact of aging on intestinal mucosal immune function and clinical applications.Frontiers in immunology · 2022Review
- The Multiple Faces of Integrin-ECM Interactions in Inflammatory Bowel Disease.International journal of molecular sciences · 2021Review
- The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies.Medicinal research reviews · 2020Review
- AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation.Journal of Crohn's & colitis · 2018Observational
- The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.Cancer immunology, immunotherapy : CII · 2016Article
- Article
- The role of the intestinal context in the generation of tolerance and inflammation.Clinical & developmental immunology · 2012Review
- The light and dark sides of intestinal intraepithelial lymphocytes.Nature reviews. Immunology · 2011Review
- Ocular surface epithelium induces expression of human mucosal lymphocyte antigen (HML-1) on peripheral blood lymphocytes.The British journal of ophthalmology · 2004Article
- The number of intraepithelial T cells decreases from ascending colon to rectum.Journal of clinical pathology · 2003Article
- Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas.Clinical and experimental immunology · 2001Article
- Staphylococcal enterotoxin B induces potent cytotoxic activity by intraepithelial lymphocytes.Immunology · 2000Article
- Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease.Gastroenterology · 2000Article
- Alpha E beta 7.Molecular pathology : MP · 1999Review
- Integrin alpha1beta1 (VLA-1) mediates adhesion of activated intraepithelial lymphocytes to collagen.Immunology · 1999Article
- Article
- Interactions between peripheral blood CD8 T lymphocytes and intestinal epithelial cells (iEC).Clinical and experimental immunology · 1998Article
- Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts.The Journal of experimental medicine · 1996Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Human intestinal intraepithelial lymphocytes (IEL) demonstrate target cell-restricted spontaneous cytotoxic (SC) activity that is due to CD2+CD3+CD8+CD16-CD56- effector cells; they kill epithelial cell (EC) tumours (such as DLD-1 colon cancer cells), but not natural killer (NK)-sensitive K-562 cells. The present study shows that the measured levels of SC activities by IEL correlated with those of autologous lamina propria lymphocytes (LPL), but not with those of peripheral blood lymphocytes (PBL). Also, the susceptibilities of DLD-1 cell clones to lysis by IEL and PBL effector cells did not correlate, suggesting different mechanisms of lysis. Antibody blocking experiments showed that the main surface molecules involved in lysis depended on the effector cell type: alpha E beta 7 (HML-1) on IEL and CD16 on PBL. No antibody-dependent cell-mediated cytotoxicity (ADCC) was demonstrated by IEL, even after stimulation with interferon-gamma (IFN-gamma). Few IEL expressed Fc receptors for IgG. This study describes further differences between the SC activities of IEL and PBL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.