ArticleAnatomy and embryology1993
The ventralizing effect of the notochord on somite differentiation in chick embryos.
Article in Anatomy and embryology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A Spatio-Temporal-Dependent Requirement of Sonic Hedgehog in the Early Development of Sclerotome-Derived Vertebrae and Ribs.International journal of molecular sciences · 2024Article
- Genome-wide identification of notochord enhancers comprising the regulatory landscape of the brachyury locus in mouse.Development (Cambridge, England) · 2023Article
- Local modulation of the Wnt/β-catenin and bone morphogenic protein (BMP) pathways recapitulates rib defects analogous to cerebro-costo-mandibular syndrome.Journal of anatomy · 2020Article
- Somite development in the avian tail.Journal of anatomy · 2019Article
- The effects of lead on the development of somites in chick embryos (Toxicology research · 2019Article
- The role of the notochord in amniote vertebral column segmentation.Developmental biology · 2018Article
- Notochord Cells in Intervertebral Disc Development and Degeneration.Journal of developmental biology · 2016Article
- Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.PLoS genetics · 2013Article
- Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Birth defects research. Part B, Developmental and reproductive toxicology · 2007Review
- Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage.The Journal of cell biology · 2007Article
- Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis.Genes & development · 2002Article
- Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling.Genes & development · 1999Article
- The identification of novel sequences expressed in the mouse notochord.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Regulation of patched by sonic hedgehog in the developing neural tube.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Axial structures control laterality in the distribution pattern of endothelial cells.Anatomy and embryology · 1996Article
- Morphological analysis of the role of the neural tube and notochord in the development of somites.Anatomy and embryology · 1995Article
- Pax-1 in the development of the cervico-occipital transitional zone.Anatomy and embryology · 1995Article
- Early stages of chick somite development.Anatomy and embryology · 1995Review
- Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos.Anatomy and embryology · 1995Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dorso-ventral pattern formation of the somites becomes manifest by the formation of the epithelially organized dorsal dermomyotome and the mesenchymal ventrally situated sclerotome. While the dermomyotome gives rise to dermis and muscle, the sclerotome differentiates into cartilage and bone of the axial skeleton. The onset of muscle differentiation can be visualized by immunohistochemistry for proteins associated with muscle contractility, e.g. desmin. The sclerotome cells and the epithelial ventral half of the somite express Pax-1, a member of a gene family with a sequence similarity to Drosophila paired-box-containing genes. In the present study, changes of Pax-1 expression were studied after grafting an additional notochord into the paraxial mesoderm region. The influence of the notochord and the floor-plate on dermomyotome formation and myotome differentiation has also been investigated. The notochord is found to exert a ventralizing effect on the establishment of the dorso-ventral pattern in the somites. Notochord grafts lead to a suppression of the formation and differentiation of the dorsal somitic derivatives. Simultaneously, a widening of the Pax-1-expressing domain in the sclerotome can be observed. In contrast, grafted roof-plate and aorta do not interfere with dorso-ventral patterning of the somitic derivatives.
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