Trial reportStroke1993
One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy.
Trial report in Stroke, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000599. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cholesterol-Lowering Atherosclerosis Study (CLAS)
ARBITER 6: ARterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6 - HDL and LDL Treatment Strategies in Atherosclerosis (HALTS)
Who cites it
21 citing papers in PubMed, 126 citations in OpenAlex.
- Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS).Fertility and sterility · 2013Trial
- Trial
- Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans.Stroke · 2000Trial
- A randomized controlled trial of meditation and health education on carotid intima-media thickness and major adverse cardiovascular events in Black men and women.Frontiers in medicine · 2025Article
- Article
- Arterial Stiffness and Chronic Kidney Disease.Pulse (Basel, Switzerland) · 2016Article
- Carotid intima-media thickness studies: study design and data analysis.Journal of stroke · 2013Review
- Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization.Molecular pharmacology · 2012Article
- Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: relationships with coronary disease severity.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2011Article
- Distinct kinetic and spatial patterns of protein kinase C (PKC)- and epidermal growth factor receptor (EGFR)-dependent activation of extracellular signal-regulated kinases 1 and 2 by human nicotinic acid receptor GPR109A.The Journal of biological chemistry · 2011Article
- Utility of atherosclerosis imaging in the evaluation of high-density lipoprotein-raising therapies.Current atherosclerosis reports · 2011Review
- Arterial remodeling associates with CKD progression.Journal of the American Society of Nephrology : JASN · 2011Article
- Comparison of common carotid artery intima-media thickness between Brazilian Euro-descendants and Afro-descendants with atherosclerosis risk factors.Clinics (Sao Paulo, Brazil) · 2009Article
- Does nicotinic acid (niacin) lower blood pressure?International journal of clinical practice · 2009Review
- A practical protocol to measure common carotid artery intima-media thickness.Clinics (Sao Paulo, Brazil) · 2008Article
- Smoking status and common carotid artery intima-medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study.BMC cardiovascular disorders · 2006Article
- Place of drug therapy in the treatment of carotid stenosis.CNS drugs · 2005Review
- What is the cardioprotective role of hormone replacement therapy?Current atherosclerosis reports · 2003Review
- Treatment of lipid disorders after stroke.Current atherosclerosis reports · 2002Review
- Postmenopausal hormone replacement therapy as antiatherosclerotic therapy.Current atherosclerosis reports · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe Cholesterol Lowering Atherosclerosis Study has reported significant reduction of coronary artery disease and of carotid arterial intima-media thickness (IMT) at 2 and 4 years with colestipol/niacin therapy. We now report on treatment effects on carotid IMT at 6 months and 1 year.
methodsOne hundred eighty-eight nonsmoking men, aged 40 to 59 years, with prior coronary artery bypass graft surgery were randomized to colestipol/niacin plus diet therapy or placebo plus diet therapy. Computerized image processing of carotid ultrasound films was used to measure IMT in the right common carotid artery. Treatment group comparisons were made at 6 months and 1 year (46 and 33 subjects, respectively, with baseline and 6-month or 1-year ultrasound measures). The time course of the treatment effect on carotid IMT was estimated using the complete sample of 78 subjects with baseline and on-trial data.
resultsNo significant treatment group differences on carotid IMT were found at 6 months. At 1 year, the treated group showed significant reduction of carotid IMT (P = .01 between groups). The placebo group showed continuing progression of IMT during the 4-year study period (estimated progression rate, 0.018 mm/y). The treated group showed reduction of IMT during the first 3 years and a plateau during the remainder of the study.
conclusionsReduction of carotid IMT was found with aggressive lipid-lowering therapy. Ultrasound measures of IMT offer a noninvasive and precise measure of early carotid atherosclerosis that will decrease sample size requirements, potentially decrease dropout rates, and widen the study population of antiatherosclerotic clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.