ArticleProceedings of the National Academy of Sciences of the United States of America1993
Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 70 citations in OpenAlex.
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- Divergent cAMP signaling differentially regulates serotonin-induced spinal motor plasticity.Neuropharmacology · 2017Article
- Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different.Frontiers in cellular neuroscience · 2017Article
- The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Textural guidance cues for controlling process outgrowth of mammalian neurons.Lab on a chip · 2009Article
- Defining memories by their distinct molecular traces.Trends in neurosciences · 2008Article
- Comparative studies of the effects of chlorpromazine and 5,6-dihydroxytryptamine on locomotion, defensive reactions in the snail Helix lucorum, and command neuron excitability in long-term sensitization.Neuroscience and behavioral physiology · 2006Article
- Coregulation of glutamate uptake and long-term sensitization in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The two regulatory subunits of aplysia cAMP-dependent protein kinase mediate distinct functions in producing synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Electrophysiological studies of the effects of 5,6-dihydroxytryptamine on the acquisition of a conditioned defensive reflex in snails.Neuroscience and behavioral physiology · 2003Article
- Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats.The Journal of physiology · 2000Article
- Use-dependent decline of paired-pulse facilitation at Aplysia sensory neuron synapses suggests a distinct vesicle pool or release mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Binding of serotonin to receptors at multiple sites is required for structural plasticity accompanying long-term facilitation of Aplysia sensorimotor synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Site-specific and sensory neuron-dependent increases in postsynaptic glutamate sensitivity accompany serotonin-induced long-term facilitation at Aplysia sensorimotor synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- A developmental gene (Tolloid/BMP-1) is regulated in Aplysia neurons by treatments that induce long-term sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Dynamics of induction and expression of long-term synaptic facilitation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term synaptic facilitation at the connections of Aplysia sensory neurons onto their target cells involves alterations in gene expression. How then are the relevant cellular signals for the induction and expression of long-term synaptic changes conveyed between the nucleus and remote synaptic terminals? We have explored this question using a set of remote, peripheral terminals of siphon sensory cells, which are approximately 3 cm from the sensory cell body in the abdominal ganglion. We found that these remote synapses, like the proximal synapses previously studied in dissociated cell culture, can exhibit long-term facilitation 24 hr after cell-wide serotonin application. Furthermore, serotonin applications restricted to the remote synaptic terminals nevertheless produced long-term facilitation, indicating that signals generated in synaptic regions can trigger the long-term process, perhaps via retrograde signals to the nucleus to modify gene expression, followed by anterograde signals back to the terminal. Serotonin applications restricted to the cell body and proximal synapses of the sensory neuron also produced long-term facilitation at remote synapses, although to a lesser extent, suggesting that long-term facilitation is expressed cell-wide, but that superimposed on this cell-wide facilitation there appears to be a component that is synapse-specific.
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