ArticleProceedings of the National Academy of Sciences of the United States of America1993
The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 179 citations in OpenAlex.
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- Developmental and Housekeeping Genes: Two Types of Genetic Organization in theInternational journal of molecular sciences · 2024Review
- An epigenetic change in a moth is generated by temperature and transmitted to many subsequent generations mediated by RNA.PloS one · 2024Article
- Transgenerational effect of drug-mediated inhibition of LSD1 on eye pigment expression in Drosophila.BMC ecology · 2020Article
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- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.Genetics · 2016Article
- Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture.Genes · 2015Review
- A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila.Genes & development · 2015Article
- Chromator protein directly interacts with the common part of the Drosophila melanogaster Mod(mdg4) family proteins.Doklady. Biochemistry and biophysics · 2014Article
- MOD(MDG4)-64.2 protein, isoform of MOD(MDG4) loci, directly interacts with the Tweedle protein family of Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2013Article
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors.Genetics · 2011Article
- Phylogenetics and evolution of Su(var)3-9 SET genes in land plants: rapid diversification in structure and function.BMC evolutionary biology · 2011Article
- Transgenerational epigenetic inheritance: more questions than answers.Genome research · 2010Review
- Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila.Current genomics · 2008Article
- Chromatin insulators: regulatory mechanisms and epigenetic inheritance.Molecular cell · 2008Review
- The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila.Chromosoma · 2008Article
- A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development.Genome biology · 2008Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila modifying mutations of position-effect variegation have been successfully used to genetically dissect chromatin components. The enhancer of position-effect variegation E(var)3-93D [formerly E-var(3)3] encodes proteins containing a domain common to the transcriptional regulators tramtrack and the products of the Broad complex. It interacts with a number of chromatin genes that suppress position-effect variegation. Mutations in E(var)3-93D exhibit an imprinting-like effect on the Y chromosome. This effect is transmitted paternally over several generations. Homeotic transformations in E(var)3-93D mutants indicate an involvement of the gene products in regulation of homeotic gene complexes. An antiserum raised against E(var)3-93D protein detects this chromosomal protein in a large subset of sites in polytene chromosomes. Our genetic and molecular data suggest that the proteins of E(var)3-93D are generally involved in establishing and/or maintaining an open chromatin conformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.