ArticleProceedings of the National Academy of Sciences of the United States of America1993
TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- TAP1 I333V gene polymorphism and type 1 diabetes mellitus: a meta-analysis of 2248 cases.Journal of cellular and molecular medicine · 2014Pooled it
- BRD2 and TAP-1 genes and juvenile myoclonic epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Article
- Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison.The review of diabetic studies : RDS · 2005Article
- Superantigens in insulin-dependent diabetes mellitus.Springer seminars in immunopathology · 1996Review
- Molecular mechanisms of class I major histocompatibility complex antigen processing and presentation.Immunologic research · 1996Review
- HLA DQA1-DQB1-TAP2 haplotypes in IDDM families: no evidence for an additional contribution to disease risk by the TAP2 locus.Diabetologia · 1995Article
- Reproductive failure and the major histocompatibility complex.American journal of human genetics · 1995Article
- Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- New polymorphisms within the human TAP1 and TAP2 coding regions.Immunogenetics · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It has been previously demonstrated that individuals with certain DR alleles have an increased relative risk of developing insulin-dependent diabetes mellitus (IDDM). The disease association is even stronger with certain DQ alleles but there is little association with DP providing a boundary of disease association to the 430 kb between DQ and DP. The recently described TAP (transporter associated with antigen processing) genes have been mapped approximately midway between DP and DQ. Therefore, it was of interest to determine if any TAP alleles were associated with IDDM. In addition to the alleles of TAP1 that have been described, others were identified during this study. Diabetics and normal controls were screened for TAP1 using single-stranded conformational polymorphism and relative risk was determined. In the same population group we have studied extensively in the past, we found a higher association of a TAP1 allele with IDDM than with any single HLA-DP allele but the risk was lower than with HLA-DQB1*0302. These data provide new limits for IDDM susceptibility to the 190-kb interval between TAP1 and HLA-DQB1.
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