ArticleProceedings of the National Academy of Sciences of the United States of America1993
Transcriptional organization of a 450-kb region of the human X chromosome in Xq28.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
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- Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria.Journal of neurochemistry · 2008Article
- The systematic functional characterisation of Xq28 genes prioritises candidate disease genes.BMC genomics · 2006Article
- X-linked cardioskeletal myopathy and neutropenia (Barth syndrome) (MIM 302060).Journal of inherited metabolic disease · 1999Review
- The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.Genetics · 1999Article
- Physical and comparative mapping of distal mouse chromosome 16. 5 p5.Genome research · 1998Article
- Mutations in GDI1 are responsible for X-linked non-specific mental retardation.Nature genetics · 1998Article
- A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility.American journal of human genetics · 1998Article
- Isolation and characterization of the QM promoter.Nucleic acids research · 1996Article
- The locus for a novel syndromic form of neuronal intestinal pseudoobstruction maps to Xq28.American journal of human genetics · 1996Article
- A compositional map of human chromosome band Xq28.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI).Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In this paper, we report the transcriptional organization of a 450-kb gene cluster in Xq28, flanked by the glucose-6-phosphate dehydrogenase and the color vision genes. CpG islands previously identified and mapped to distal Xq28 have helped in construction of a continuous contig of cosmids and in identification of cDNAs corresponding to eight transcripts. Thirteen to 16 small genes with CpG islands are clustered in a region of 250-300 kb. Many are highly expressed in muscle or brain and may be the genes responsible for muscle or neurological disorders mapped to distal Xq28. Our analysis indicates that, in this region of the genome, genes not related in sequence are organized in transcriptional domains of 100 kb and that this organization may be important for establishing and regulating gene expression in relation to tissue distribution and X chromosome inactivation.
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