ArticleProceedings of the National Academy of Sciences of the United States of America1993
Overexpression of human loricrin in transgenic mice produces a normal phenotype.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 68 citations in OpenAlex.
- Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis.International dental journal · 2023Article
- The KEAP1/NRF2 Signaling Pathway in Keratinization.Antioxidants (Basel, Switzerland) · 2020Review
- A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment.Journal of molecular cell biology · 2019Article
- Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.The Journal of investigative dermatology · 2015Article
- Analysis of the expression pattern of involucrin in human scalp skin and hair follicles: hair cycle-associated alterations.Histochemistry and cell biology · 2012Article
- Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.The Journal of biological chemistry · 2010Article
- Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6.Clinical immunology (Orlando, Fla.) · 2008Article
- Transcription factor regulation of epidermal keratinocyte gene expression.Molecular biology reports · 1996Review
- Loricrin - an overview.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cornified cell envelope (CE) of terminally differentiating stratified squamous epithelial cells is a complex multiprotein assembly about 15 nm thick of which loricrin is a major component. We have produced transgenic mice bearing the human loricrin transgene in order to study the role of loricrin in CE assembly, structure, and function. By analyses of RNA and protein, we show that the human transgene is expressed in mouse epithelial tissues in an appropriate developmental manner but at an overall level about twice that of endogenous mouse loricrin. Thus the 20-kbp construct used contains all necessary regulatory elements. By immunogold electron microscopy, all of the expressed protein is incorporated into the CE. That no alternations were noted indicates that overproduction of the loricrin component of the CE does not affect the flexible structure or function of the epithelial tissues. Furthermore, these data imply that loricrin may be the last protein to be deposited onto, and thus lines, the intracellular surface of the CE, where it may be accessible to interact with the subjacent keratin intermediate-filament network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.