ArticleProceedings of the National Academy of Sciences of the United States of America1993
Isolation of a shark immunoglobulin light chain cDNA clone encoding a protein resembling mammalian kappa light chains: implications for the evolution of light chains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Camelid Single-Domain Antibodies as Tools for Novel Target Identification in Kinetoplastid Research.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Affimers and nanobodies as molecular probes and their applications in imaging.Journal of cell science · 2022Article
- The immunoglobulins of cartilaginous fishes.Developmental and comparative immunology · 2021Review
- Fish Immunoglobulins.Biology · 2016Review
- Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions.Frontiers in immunology · 2016Article
- Beyond peptides and mAbs--current status and future perspectives for biotherapeutics with novel constructs.Journal of clinical pharmacology · 2015Review
- Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Origin and evolution of the adaptive immune system: genetic events and selective pressures.Nature reviews. Genetics · 2010Review
- Molecular and expression analysis of complement component C5 in the nurse shark (Ginglymostoma cirratum) and its predicted functional role.Fish & shellfish immunology · 2009Article
- Identification of Igsigma and Iglambda in channel catfish, Ictalurus punctatus, and Iglambda in Atlantic cod, Gadus morhua.Immunogenetics · 2009Article
- Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates.European journal of immunology · 2007Article
- Diverse immunoglobulin light chain organizations in fish retain potential to revise B cell receptor specificities.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- The complexity of expressed kappa light chains in egg-laying mammals.Immunogenetics · 2004Article
- Characterization and expression of the immunoglobulin light chain in the fugu: evidence of a solitaire type.Immunogenetics · 2004Article
- The natural antibody repertoire of sharks and humans recognizes the potential universe of antigens.The protein journal · 2004Article
- Rearrangement of immunoglobulin genes in shark germ cells.The Journal of experimental medicine · 2000Article
- Sequence and characterization of two HSP70 genes in the colonial protochordate Botryllus schlosseri.Immunogenetics · 1996Article
- Generation of immunoglobulin light chain gene diversity in Raja erinacea is not associated with somatic rearrangement, an exception to a central paradigm of B cell immunity.The Journal of experimental medicine · 1995Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The time of emergence of immunoglobulin kappa and lambda light (L) chains in evolution is unknown. An L chain cDNA clone was isolated from the nurse shark (Ginglymostoma cirratum), a cartilaginous fish, whose predicted variable (V) region amino acid sequence has up to 60% sequence identity to mammalian V kappa domains. Genomic analyses suggest a cluster-type gene organization for this L chain locus, similar to the shark lambda-like immunoglobulin L chain loci rather than mammalian kappa loci. We propose that divergence of the ancestral L chain into isotypes likely occurred before the emergence of elasmobranchs 400-450 million years ago. Similarities in gene organization between the two isotypes in sharks may reflect the gene organization utilized by the ancestral L chain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.