ArticleProceedings of the National Academy of Sciences of the United States of America1993
Multiple loci for synapse protein SNAP-25 in the tetraploid goldfish.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 71 citations in OpenAlex.
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- A High-Density Genetic Linkage Map and QTL Fine Mapping for Body Weight in Crucian Carp (G3 (Bethesda, Md.) · 2017Article
- Tempo and mode of recurrent polyploidization in the Carassius auratus species complex (Cypriniformes, Cyprinidae).Heredity · 2014Article
- Embryonic development of goldfish (Carassius auratus): a model for the study of evolutionary change in developmental mechanisms by artificial selection.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina.Neuroscience · 2010Article
- Automated identification of conserved synteny after whole-genome duplication.Genome research · 2009Article
- Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish.Genome research · 2004Article
- Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus).Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Multiple forms of complement C3 in trout that differ in binding to complement activators.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Regulated vesicular fusion in neurons: snapping together the details.Proceedings of the National Academy of Sciences of the United States of America · 1994Review
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2 authors at 1 institution in 1 country.
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Abstract
The common goldfish Carassius auratus is tetraploid and has 100 chromosomes. We describe here goldfish cDNA clones for SNAP-25, a 200-amino-acid synaptosome-associated protein that has remained highly conserved during evolution. SNAP-25 occurs as a single-copy gene in mouse, chicken, and Drosophila melanogaster. Sequences of six distinct goldfish cDNA clones and Southern hybridizations show that the goldfish has three, or possibly four, SNAP-25 loci rather than two as expected. A gene duplication early in actinopterygian fish evolution gave rise to the loci SnapA and SnapB. The proteins SNAP-A and SNAP-B are 94% and 91% identical to the mouse protein but are only 91% identical to each other. SNAP-B has a larger number of unique amino acid replacements than SNAP-A and also has more dramatic replacements. The tetraploidization resulted in two SnapB loci whose divergence from each other is consistent with a tetraploidization event 15-20 million years ago. The presence of duplicate SnapA loci has not yet been possible to confirm, possibly because they are still very similar to each other. Two of the SnapA cDNA clones and one SnapB cDNA clone have frameshift mutations. As these aberrant alleles otherwise display high sequence identity to the functional alleles, they probably became nonfunctional recently. The findings of allelic variability and aberrant alleles emphasize the importance of characterizing multiple DNA clones in tetraploid species.
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