ArticleMolecular and cellular biology1993
Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Analysis of primitive erythroid cell proliferation and enucleation using a cyan fluorescent reporter in transgenic mice.Genesis (New York, N.Y. : 2000) · 2013Article
- The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells.ISRN hematology · 2013Review
- Article
- Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.Experimental biology and medicine (Maywood, N.J.) · 2006Article
- Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.Genome research · 2005Article
- A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Histone- and protamine-DNA association: conservation of different patterns within the beta-globin domain in human sperm.Molecular and cellular biology · 1998Article
- The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene.Molecular and cellular biology · 1998Article
- Induction of basic helix-loop-helix protein-containing complexes during erythroid differentiation.Gene expression · 1998Article
- Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Essential role of NF-E2 in remodeling of chromatin structure and transcriptional activation of the epsilon-globin gene in vivo by 5' hypersensitive site 2 of the beta-globin locus control region.Molecular and cellular biology · 1996Article
- A DNA-bending protein interacts with an essential upstream regulatory element of the human embryonic beta-like globin gene.Molecular and cellular biology · 1996Article
- Developmental regulation of the vertebrate globin multigene family.Gene expression · 1996Review
- A novel developmental regulatory motif required for stage-specific activation of the epsilon-globin gene and nuclear factor binding in embryonic erythroid cells.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The stage-specific regulation of mammalian embryonic globin genes has been an experimentally elusive problem, in part because of the developmentally early timing of their expression. We have carried out a systematic analysis of truncation and internal deletion mutations within the 5'-flanking region of the human embryonic beta-like globin gene (epsilon) in erythroid and nonerythroid cell lines. Within a 670-bp region upstream from the constitutive promoter are multiple positive and negative control elements. Of these, a positive regulatory element (epsilon-PRE II) which is active only in embryonic erythroid cells is of particular interest. Remarkably, although it is inactive on its own, in the presence of other sequences located further upstream, it confers tissue- and developmental stage-specific expression on a constitutive epsilon-globin or heterologous promoter. The activity of epsilon-PRE II is also modulated by another positive regulatory domain located further downstream to direct erythroid cell-specific, but little or no embryonic stage-specific, transcription. A nuclear factor highly enriched in embryonic erythroid cells binds specifically within a 19-bp region of epsilon-PRE II. Nuclei from adult erythroid cells also contain a factor that binds to this region but forms a complex of faster electrophoretic mobility. We speculate that interactions between epsilon-PRE II and other upstream control elements play an important role in the developmental regulation of the human embryonic beta-like globin gene.
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