ArticleMolecular and cellular biology1993
Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 93 citations in OpenAlex.
- Identification of a novel gene signature for neuroblastoma differentiation using a Boolean implication network.Genes, chromosomes & cancer · 2023Article
- The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer.Journal of Cancer · 2022Review
- How scars shape the neural landscape: Key molecular mediators of TGF-β1's anti-neuritogenic effects.PloS one · 2020Article
- Cell death-based treatment of neuroblastoma.Cell death & disease · 2018Review
- Discovering cancer vulnerabilities using high-throughput micro-RNA screening.Nucleic acids research · 2017Article
- TrkA is a binding partner of NPM-ALK that promotes the survival of ALKMolecular oncology · 2017Article
- Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.Cancer science · 2015Article
- Characterization of critical domains within the tumor suppressor CASZ1 required for transcriptional regulation and growth suppression.Molecular and cellular biology · 2012Article
- Tumor necrosis factor alpha regulates responses to nerve growth factor, promoting neural cell survival but suppressing differentiation of neuroblastoma cells.Molecular biology of the cell · 2008Article
- A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation.PloS one · 2008Article
- NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number.Oncogene · 2004Article
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- Gastrin-releasing peptide is a growth factor for human neuroblastomas.Annals of surgery · 2002Article
- Expression of the ALK tyrosine kinase gene in neuroblastoma.The American journal of pathology · 2000Article
- Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells.Oncogene · 2000Article
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- Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Differentiation and growth inhibition of glioma cells induced by transfer of trk A proto-oncogene.Journal of neuro-oncology · 1999Article
- Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The human trkA cDNA was transfected into a malignant human neuroblastoma (NB) cell line (HTLA230) to investigate its role in NB growth and differentiation. This cell line lacks expression of both endogenous trkA and gp75NGFR genes. Transfectants expressing the trkA mRNA and surface-bound receptors transcriptionally activate immediate-early genes (c-fos, c-jun, and jun-B) following nerve growth factor (NGF) stimulation. NGF treatment induces growth arrest as well as down-regulation of the amplified N-myc oncogene. Genes selectively expressed in mature neurons (SCG-10, ret proto-oncogene, GAP-43, etc.) are transcriptionally activated, and neurite outgrowth further demonstrates differentiation of transfectants following NGF stimulation. trkA-expressing NB cells remain tumorigenic in nude mice; however, subcutaneous treatment of tumor-bearing mice with NGF induces Schwannian and neuronal cell differentiation similar to the induction seen in human ganglioneuroblastomas. Thus, trkA expression in HTLA230 cells is sufficient to generate a functional NGF receptor complex that leads to growth-arrested and differentiated NB cells in vitro and in vivo in the presence of NGF. Hence, NGF may play a crucial role in NB cell differentiation and regression in vivo.
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