ArticleMolecular and cellular biology1993
E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.Scientific reports · 2019Article
- SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.Cell reports · 2018Article
- E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia.Leukemia · 2011Article
- Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability.Mechanisms of ageing and development · 2010Article
- Identification of cyclin D3 as a direct target of E2A using DamID.Molecular and cellular biology · 2004Article
- Article
- Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2.Molecular and cellular biology · 2002Article
- Gradient of E2A activity in B-cell development.Molecular and cellular biology · 2002Article
- Article
- Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator.The Journal of biological chemistry · 1999Article
- Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice.Molecular and cellular biology · 1999Article
- Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation.The American journal of pathology · 1998Article
- Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.Molecular and cellular biology · 1997Article
- Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins.Molecular and cellular biology · 1997Article
- The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis.Molecular and cellular biology · 1997Article
- Phosphorylation of E47 as a potential determinant of B-cell-specific activity.Molecular and cellular biology · 1996Article
- Various modes of basic helix-loop-helix protein-mediated regulation of murine leukemia virus transcription in lymphoid cell lines.Journal of virology · 1996Article
- Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Substitution of basic amino acids in the basic region stabilizes DNA binding by E12 homodimers.Nucleic acids research · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A monoclonal antibody (Yae) was characterized and shown to specifically recognize E2A proteins in vivo, including the E2A-Pbx1 fusion gene products, p77E2A-Pbx1 and p85E2A-Pbx1. E2A proteins of a predominant molecular mass of 72 kDa, which comigrated with in vitro-produced rat E12 and and rat E47, were detected in human pro-B, pre-B, mature B, and plasma cell lines. The Yae antibody detected an E2A-containing microE2 enhancer element-binding complex (BCF-1) in pre-B- and mature B-cell lines in electrophoretic mobility shift assays which displayed a migration rate similar to that of in vitro-produced rat E12 and rat E47. A new E2A-containing microE2-binding species (P-E2A) was identified in plasma cells by using electrophoretic mobility shift assays. E2A proteins were detected in pro-B cells but were unable to bind the microE2 site. These observations suggest that the microE2 site is the target of stage-specific E2A regulatory complexes during B-cell development. Immunostaining analyses demonstrated the predominant nuclear localization of E2A proteins. Finally, we have identified an E2A form, designated I-E2A, which is unable to bind DNA. Our observations demonstrate novel in vivo mechanisms for the regulation of transcription by E2A proteins during B-cell development.
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