ArticleMolecular and cellular biology1993
A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Nucleic Acid Sensing Pathways in DNA Repair Targeted Cancer Therapy.Frontiers in cell and developmental biology · 2022Review
- The amino-terminal tails of histones H2A and H3 coordinate efficient base excision repair, DNA damage signaling and postreplication repair in Saccharomyces cerevisiae.Nucleic acids research · 2015Article
- TLR signaling and DNA repair: are they associated?The Journal of investigative dermatology · 2013Review
- Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes.Nucleic acids research · 2006Article
- Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element.Nucleic acids research · 2004Article
- Homologous recombination is essential for RAD51 up-regulation in Saccharomyces cerevisiae following DNA crosslinking damage.Nucleic acids research · 2002Article
- The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes.Genes & development · 2001Article
- Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes.Molecular and cellular biology · 2000Article
- Global response of Saccharomyces cerevisiae to an alkylating agent.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Generation of a strong mutator phenotype in yeast by imbalanced base excision repair.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Article
- Role of UME6 in transcriptional regulation of a DNA repair gene in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
- Identification of the DNA damage-responsive elements of the rhp51+ gene, a recA and RAD51 homolog from the fission yeast Schizosaccharomyces pombe.Molecular & general genetics : MGG · 1996Article
- 3-methyladenine-DNA-glycosylase and O6-alkyl guanine-DNA-alkyltransferase activities and sensitivity to alkylating agents in human cancer cell lines.British journal of cancer · 1996Article
- Regulation of SNM1, an inducible Saccharomyces cerevisiae gene required for repair of DNA cross-links.Molecular & general genetics : MGG · 1996Article
- Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage.Nucleic acids research · 1995Article
- Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae.Nucleic acids research · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Saccharomyces cerevisiae MAG gene encodes a 3-methyladenine DNA glycosylase that protects cells from killing by alkylating agents. MAG mRNA levels are induced not only by alkylating agents but also by DNA-damaging agents that do not produce alkylated DNA. We constructed a MAG-lacZ gene fusion to help identify the cis-acting promoter elements involved in regulating MAG expression. Deletion analysis defined the presence of one upstream activating sequence and one upstream repressing sequence (URS) and suggested the presence of a second URS. One of the MAG URS elements matches a decamer consensus sequence present in the promoters of 11 other S. cerevisiae DNA repair and metabolism genes, including the MGT1 gene, which encodes an O6-methylguanine DNA repair methyltransferase. Two proteins of 26 and 39 kDa bind specifically to the MAG and MGT1 URS elements. We suggest that the URS-binding proteins may play an important role in the coordinate regulation of these S. cerevisiae DNA repair genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.