ReviewMicrobiological reviews1993
Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance.
Review in Microbiological reviews, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
127 citing papers in PubMed, 414 citations in OpenAlex.
- Investigating the effects of thymol and cinnamaldehyde in T-2 toxin-treated hepatic cell cultures of chicken origin.Poultry science · 2026Article
- Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds.Stress biology · 2026Article
- T-2 Toxin Neurotoxicity: Molecular Mechanisms and Emerging Chemoprotective Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Pilot-scale fermentation to produce trichodiene, a fungal volatile that suppresses trichothecene production in mycotoxigenic fungi.Applied and environmental microbiology · 2026Article
- Culture Condition-Dependent Acylation Patterns of Trichothecenes in a T-2 Toxin-Producing Strain ofInternational journal of molecular sciences · 2026Article
- Cross-Kingdom Enzymatic Strategies for Deoxynivalenol Detoxification: Computational Analysis of Structural Mechanisms and Evolutionary Adaptations.Microorganisms · 2025Article
- The TOX2 Gene Is Responsible for Conidiation and Full Virulence inCurrent issues in molecular biology · 2025Article
- Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation.European journal of nutrition · 2025Article
- Individual and combined occurrences of the prevalent mycotoxins in commercial feline and canine food.Mycotoxin research · 2024Review
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- Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-aBIOTECH · 2023Review
- Inter-laboratory study on simultaneous quantification of ten trichothecenes in feed.Mycotoxin research · 2023Article
- Review
- Regulatory mechanism of trichothecene biosynthesis inFrontiers in microbiology · 2023Article
- Pathogenesis and defense mechanism while Beauveria bassiana JEF-410 infects poultry red mite, Dermanyssus gallinae.PloS one · 2023Article
- Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications.Antioxidants (Basel, Switzerland) · 2022Review
- Polaramycin B, and not physical interaction, is the signal that rewires fungal metabolism in the Streptomyces-Aspergillus interaction.Environmental microbiology · 2022Article
- Mitochondrial Porin Is Involved in Development, Virulence, and Autophagy inJournal of fungi (Basel, Switzerland) · 2022Article
- Structure-function characterization of an aldo-keto reductase involved in detoxification of the mycotoxin, deoxynivalenol.Scientific reports · 2022Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several species of the genus Fusarium and related fungi produce trichothecenes which are sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis. Interest in the trichothecenes is due primarily to their widespread contamination of agricultural commodities and their adverse effects on human and animal health. In this review, we describe the trichothecene biosynthetic pathway in Fusarium species and discuss genetic evidence that several trichothecene biosynthetic genes are organized in a gene cluster. Trichothecenes are highly toxic to a wide range of eukaryotes, but their specific function, if any, in the survival of the fungi that produce them is not obvious. Trichothecene gene disruption experiments indicate that production of trichothecenes can enhance the severity of disease caused by Fusarium species on some plant hosts. Understanding the regulation and function of trichothecene biosynthesis may aid in development of new strategies for controlling their production in food and feed products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.