ArticleThe Journal of experimental medicine1993
Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide.
Article in The Journal of experimental medicine, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Peptide Loading Complex in Cancer: From Peptide Translocation, Editing, and Loading into MHC-I to a Potential Therapeutic Target.Current medical science · 2026Review
- Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.British journal of cancer · 2020Article
- Strict Assembly Restriction of Peptides from Rabbit Hemorrhagic Disease Virus Presented by Rabbit Major Histocompatibility Complex Class I Molecule RLA-A1.Journal of virology · 2020Article
- The first step of peptide selection in antigen presentation by MHC class I molecules.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A negative feedback modulator of antigen processing evolved from a frameshift in the cowpox virus genome.PLoS pathogens · 2014Article
- Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading.Methods in molecular biology (Clifton, N.J.) · 2013Article
- The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Analysis of major histocompatibility complex class I folding: novel insights into intermediate forms.Tissue antigens · 2012Article
- A short isoform of human cytomegalovirus US3 functions as a dominant negative inhibitor of the full-length form.Journal of virology · 2006Article
- Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.The Journal of experimental medicine · 2006Article
- The many roads to cross-presentation.The Journal of experimental medicine · 2005Review
- Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.Journal of virology · 2001Article
- ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.The EMBO journal · 1998Article
- Article
- Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies.The Journal of experimental medicine · 1996Article
- Prediction of potential cytotoxic T lymphocyte epitopes of bovine herpesvirus 1 based on allele-specific peptide motifs and proteolytic cleavage specificities.Virus genes · 1996Article
- Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.The Journal of experimental medicine · 1995Article
- Proteasome and class I antigen processing and presentation.Molecular biology reports · 1995Review
- Species-specific differences in chaperone interaction of human and mouse major histocompatibility complex class I molecules.The Journal of experimental medicine · 1995Article
- Peptide size selection by the major histocompatibility complex-encoded peptide transporter.The Journal of experimental medicine · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) class I molecules are heterotrimers consisting of a polymorphic H chain, beta 2-microglobulin (beta 2m) and peptide. Peptides are thought to associate early during biosynthesis but the order of assembly of class I molecules from their component subunits in intact cells is not settled. We have studied the assembly of MHC class I molecules in intact cells with or without peptide transporters. MHC class I H chain/beta 2m heterodimers can be efficiently recovered only 4 min after translation and are preceded by a folding intermediate. Approximately 2 min after their formation, the class I heterodimers are loaded with peptides resulting in stable class I heterotrimers. In these in vivo studies, no evidence was obtained that peptide binding to the H chain preceded the association with beta 2m. In contrast, nonassembled class I H chains could be recovered immediately after translation, but this pool did not participate in the formation of class I molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.