ArticleImmunology1993
Suppression of murine IgM, IgG, IgA and IgE antibody responses by alveolar macrophages.
Article in Immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated M2 macrophages.Clinical & developmental immunology · 2012Review
- Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production.Infection and immunity · 2003Article
- A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis.Immunology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Freshly recovered pulmonary alveolar macrophages (AM) and the AM-derived established cell line, MH-S, have previously been shown to be highly suppressive of in vitro IgM anti-sheep erythrocyte (SRBC) responses. Supernatants obtained from cultures of AM incubated with antigen-stimulated lymphocytes or from the MH-S cell line alone have also been shown to be suppressive when added to the in vitro antibody-forming system. In order to determine if AM and MH-S cells, owing to their mucosal location, could differentially regulate antibody responses including immunoglobulin isotypes other than IgM, an in vitro system for the detection of cells producing IgG, IgA and IgE anti-2,4 dinitrophenol (DNP) antibody was developed. These studies demonstrate that AM, MH-S cells, and MH-S culture supernatants suppress the in vitro generation of IgM, IgG, IgA and IgE anti-DNP spot-forming cells (SFC). No apparent differential regulation of any of the four murine IgG anti-DNP antibody subclasses was observed. Time-course experiments suggested that optimal AM- and MH-S-mediated suppression occurred 18 hr after culture initiation. Both AM and MH-S cells suppressed IgM and IgG anti-DNP antibody responses in a dose-related manner, suggesting that MH-S is a good model for the study of AM-mediated immunoregulation.
Indexed as
Identifiers
8244465PMC1422121W162420011What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.