ArticleImmunology1993
Non-oscillatory free Ca2+ response of single B cells and WEHI-231 cells after cross-linking of antigen receptors with anti-immunoglobulin.
Article in Immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cross-linking of surface-immunoglobulin (sIg) has been associated with IP3 production and a rise in cytoplasmic-free calcium ([Ca2+]i) in studies of populations of normal and transformed B cells. We have examined the kinetics of the induced cytoplasmic calcium rises in single, Fura-2-loaded cells, during stimulation with a variety of agonists. Our data indicate that the responses of B cells to some stimuli, such as elevated cyclic AMP, consist of repetitive calcium transients, but these Ca2+ oscillations do not occur after sIg ligation. Rather, sIg cross-linking leads to a rapid rise in cytoplasmic calcium which is followed by a sustained elevation. Most of this response seems to result from an inflow of extracellular calcium rather than from internal stores.
Indexed as
Identifiers
8244463PMC1422122W2402400537What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.