ArticleGenetics1993
Screens for extragenic mutations that fail to complement act1 alleles identify genes that are important for actin function in Saccharomyces cerevisiae.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- BcTaf14 regulates growth and development, virulence, and stress responses in the phytopathogenic fungus Botrytis cinerea.Molecular plant pathology · 2023Article
- Linking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin.G3 (Bethesda, Md.) · 2014Article
- Actin dosage lethality screening in yeast mediated by selective ploidy ablation reveals links to urmylation/wobble codon recognition and chromosome stability.G3 (Bethesda, Md.) · 2013Article
- Evolutionary analysis of heterochromatin protein compatibility by interspecies complementation in Saccharomyces.Genetics · 2012Article
- Matthew Welch: The many branches of actin regulation. Interview by Ben Short.The Journal of cell biology · 2011Article
- The YEATS domain of Taf14 in Saccharomyces cerevisiae has a negative impact on cell growth.Molecular genetics and genomics : MGG · 2010Article
- INO80 subfamily of chromatin remodeling complexes.Mutation research · 2007Review
- Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.Genes & development · 2007Article
- Sometimes the result is not the answer: the truths and the lies that come from using the complementation test.Genetics · 2006Review
- Genetic interactions between TFIIF and TFIIS.Genetics · 2006Article
- The eukaryote chaperonin CCT is a cold shock protein in Saccharomyces cerevisiae.Cell stress & chaperones · 2002Article
- Article
- Generation of an isogenic collection of yeast actin mutants and identification of three interrelated phenotypes.Genetics · 2001Article
- Derepression of DNA damage-regulated genes requires yeast TAF(II)s.The EMBO journal · 2000Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
- TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.Molecular and cellular biology · 1996Article
- An extragenic suppressor of the mitosis-defective bimD6 mutation of Aspergillus nidulans codes for a chromosome scaffold protein.Genetics · 1996Article
- Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Null mutations in SAC6 and ABP1, genes that encode actin-binding proteins, failed to complement the temperature-sensitive phenotype caused by a mutation in the ACT1 gene. To identify novel genes whose protein products interact with actin, mutations that fail to complement act1-1 or act1-4, two temperature-sensitive alleles of ACT1, were isolated. A total of 14 extragenic noncomplementing mutations and 12 new alleles of ACT1 were identified in two independent screens. The 14 extragenic noncomplementing mutations represent alleles of at least four different genes, ANC1, ANC2, ANC3 and ANC4 (Actin NonComplementing). Mutations in the ANC1 gene were shown to cause osmosensitivity and defects in actin organization; phenotypes that are similar to those caused by act1 mutations. We conclude that the ANC1 gene product plays an important role in actin cytoskeletal function. The 12 new alleles of ACT1 will be useful for further elucidation of the functions of actin in yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.