ArticleMolecular biology of the cell1993
Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.
Article in Molecular biology of the cell, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 166 citations in OpenAlex.
- Systematic module approach identifies altered genes and pathways in four types of ovarian cancer.Molecular medicine reports · 2017Article
- Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.Scientific reports · 2017Article
- Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway.Biology of reproduction · 2012Article
- Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.The Journal of biological chemistry · 2012Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases.Journal of the American Chemical Society · 2010Article
- Developmental timing of mRNA translation--integration of distinct regulatory elements.Molecular reproduction and development · 2010Review
- The Xenopus cell cycle: an overview.Molecular biotechnology · 2008Review
- MAP kinase pathways: the first twenty years.Biochimica et biophysica acta · 2007Review
- How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor.Cell division · 2007Article
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.Nature · 2006Article
- B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts.Oncogene · 2006Article
- Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity.Molecular and cellular biology · 2003Article
- Mos is not required for the initiation of meiotic maturation in Xenopus oocytes.The EMBO journal · 2002Article
- Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.BMC biochemistry · 2002Article
- Cyclin B/cdc2 induces c-Mos stability by direct phosphorylation in Xenopus oocytes.Molecular biology of the cell · 2001Article
- c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mos activates MAP kinase in mouse oocytes through two opposite pathways.The EMBO journal · 2000Article
- c-mos and cdc2 cooperate in the translational activation of fibroblast growth factor receptor-1 during Xenopus oocyte maturation.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mitogen-activated protein kinases (MAPKs) are rapidly and transiently activated when both quiescent Go-arrested cells and G2-arrested oocytes are stimulated to reenter the cell cycle. We previously developed a cell-free system from lysates of quiescent Xenopus oocytes that responds to oncogenic H-ras protein by activating a MAPK, p42MAPK. Here, we show that the oncogenic protein kinase mos is also a potent activator of p42MAPK in these lysates. Mos also induces p42MAPK activation in lysates of activated eggs taken at a time when neither mos nor p42MAPK is normally active, showing that the mos-responsive MAPK activation pathway persists beyond the stage where mos normally functions. Similarly, lysates of somatic cells (rabbit reticulocytes) also retain a mos-inducible MAPK activation pathway. The mos-induced activation of MAPKs in all three lysates leads to phosphorylation of the pp90rsk proteins, downstream targets of the MAPK signaling pathway in vivo. The in vitro activation of MAPKs by mos in cell-free systems derived from oocytes and somatic cells suggests that mos contributes to oncogenic transformation by inappropriately inducing the activation of MAPKs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.