ArticleArchives of microbiology1993
Induction of pyruvate decarboxylase in glycolysis mutants of Saccharomyces cerevisiae correlates with the concentrations of three-carbon glycolytic metabolites.
Article in Archives of microbiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Genetic and Physiological Characterization of the Pentose Phosphate Pathway in the YeastInternational journal of molecular sciences · 2025Article
- Metabolomic and (13)C-metabolic flux analysis of a xylose-consuming Saccharomyces cerevisiae strain expressing xylose isomerase.Biotechnology and bioengineering · 2015Article
- Integration of metabolic modeling and phenotypic data in evaluation and improvement of ethanol production using respiration-deficient mutants of Saccharomyces cerevisiae.Applied and environmental microbiology · 2008Article
- Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae.Microbial cell factories · 2008Article
- Engineering of a novel Saccharomyces cerevisiae wine strain with a respiratory phenotype at high external glucose concentrations.Applied and environmental microbiology · 2005Article
- Regulation of glycolysis in Kluyveromyces lactis: role of KlGCR1 and KlGCR2 in glucose uptake and catabolism.Current genetics · 2004Article
- Trehalose, glycogen and ethanol metabolism in the gcr1 mutant of Saccharomyces cerevisiae.Folia microbiologica · 2003Article
- Function and regulation of yeast hexose transporters.Microbiology and molecular biology reviews : MMBR · 1999Review
- Yeast carbon catabolite repression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate.Journal of bacteriology · 1997Article
- Article
- Xylulose and glucose fermentation by Saccharomyces cerevisiae in chemostat culture.Applied and environmental microbiology · 1996Article
- Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase.Applied and environmental microbiology · 1995Article
- Different internal metabolites trigger the induction of glycolytic gene expression in Saccharomyces cerevisiae.Journal of bacteriology · 1995Article
- Open reading frames in the antisense strands of genes coding for glycolytic enzymes in Saccharomyces cerevisiae.Molecular & general genetics : MGG · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Pyruvate decarboxylase, PDCase, activity in wild-type yeast cells growing on ethanol is quite low but increases up to tenfold upon addition of glucose, less with galactose and only slightly with glycerol. PDCase levels in glycolysis mutant strains growing on ethanol or acetate were higher than in the wild-type strain. These levels correlated with the sum of the concentrations of three-carbon glycolytic metabolites. The highest accumulation was observed in a fructose bisphosphate aldolase deletion mutant concomitant with the highest PDCase activity ever observed under gluconeogenic conditions. Glucose addition induced an increase in PDCase activity in all mutants. However, the enzyme activities never reached wild-type level. On the other hand, the PDCase levels in the different mutants again correlated with the sum of the concentrations of the three-carbon glycolytic metabolites. This was interpreted to mean that full induction of PDCase activity requires the accumulation of hexose- and triosephosphates.
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